The differentiation of stem cells can be modulated by physical factors such as the micro-and
nano-topography of the extracellular matrix. One important goal in stem cell research is to …

Substrates used to culture human embryonic stem cells (hESCs) are typically 2-dimensional
(2-D) in nature, with limited ability to recapitulate in vivo-like 3-dimensional (3-D) …

Stem cells possess unique abilities as they can renew themselves for extended periods of
time and have the capacity to differentiate into a variety of lineages. They hold promise for …

Biophysical cues on the extracellular matrix (ECM) have proven to be significant regulators
of stem cell behavior and evolution. Understanding the interplay of these cells and their …

Desirable properties such as hypoimmunogenicity, multipotency, and robust self-
renewability have made adult stem cells an attractive cell source in regenerative medicine.[1 …

High-throughput screening (HTS) methods based on topography gradients or arrays have
been extensively used to investigate cell–material interactions. However, it is a huge …

Cell adhesion, orientation and migration are influenced by surface topographies in the
micrometer and nanometer range. In this work, we demonstrate the stimulation by …

The F11 hybridoma, a dorsal root ganglion-derived cell line, was used to investigate the
response of nociceptive sensory neurons to nanotopographical guidance cues. This …

The physiological microenvironment of the stem cell niche, including the three factors of
stiffness, topography, and dimension, is crucial to stem cell proliferation and differentiation …

Adhesion and spreading are essential processes of anchorage dependent cells involved in
regulation of cell functions. Cells interact with their extracellular matrix (ECM) resulting in …