Adherent cells respond to a wide range of substrate cues, including chemistry, topography,
hydrophobicity, and surface energy. The cell‐substrate interface is therefore an important …

Surface topography can have significant impact on the cell fate decisions of stem cells.
Construction of a biomaterial that can mimic the physiological microenvironment can be …

The fate of adult stem cells can be influenced by physical cues, including nanotopography.
However, the response of human embryonic stem cells (hESCs) to dimensionally well …

Biochemical and biomechanical signals regulate stem cell function in the niche
environments in vivo. Current in vitro culture of mouse embryonic stem cells (mESC) uses …

Human embryonic stem cells (hESCs) have great potentials for future cell-based
therapeutics. However, their mechanosensitivity to biophysical signals from the cellular …

Biophysical cues on the extracellular matrix (ECM) have proven to be significant regulators
of stem cell behavior and evolution. Understanding the interplay of these cells and their …

Stem cells are unspecialized cells that can self renew indefinitely and differentiate into
several somatic cells given the correct environmental cues. In the stem cell niche, stem cell …

Stem cells are known for their potential to repair damaged tissues. The adhesion, growth
and differentiation of stem cells are likely controlled by the surrounding microenvironment …

Stem cells are increasingly studied because of their potential to underpin a range of novel
therapies, including regenerative strategies, cell type-specific therapy and tissue repair …

Adult stem cell research has been advanced in recent years because of the cells' attractive
abilities of self-renewal and differentiation. Topography of materials is one of the key …