Sinonasal biomarkers defining type 2-high and type 2-low inflammation in chronic rhinosinusitis with nasal polyps

E De Corso, S Baroni, S Settimi, ME Onori… - Journal of Personalized …, 2022 - mdpi.com
The complex pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP)
generates a spectrum of phenotypes with a wide variety of inflammatory states. We enrolled …

Comprehensive evaluation of type 2 endotype and clinical features in patients with chronic rhinosinusitis with nasal polyps in Taiwan: a cross-sectional study

YT Lin, CF Lin, CK Liao, TH Yeh - European Archives of Oto-Rhino …, 2023 - Springer
Purpose Endotype-driven treatment has been introduced in the management of chronic
rhinosinusitis with nasal polyps (CRSwNP), and an understanding of the associations …

Correlation between inflammatory biomarkers and disease control in chronic rhinosinusitis with nasal polyps

E De Corso, S Baroni, S Settimi… - International forum of …, 2024 - Wiley Online Library
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) may have a heterogeneous
response to medical/surgical treatments based on endotypes. Data correlating biomarkers …

An integrated analysis of inflammatory endotypes and clinical characteristics in chronic rhinosinusitis with nasal polyps

D Hao, Y Wu, P Li, C Li, T Jiang, Q Zhang… - Journal of …, 2022 - Taylor & Francis
Objective Chronic rhinosinusitis with nasal polyps (CRSwNP) is mainly characterised by
type 1 (T1), type 2 (T2) and type 3 (T3) inflammatory endotypes. However, correlations …

Biomarkers guiding biological therapeutic strategies in chronic rhinosinusitis with nasal polyps: an emerging challenge

B Yan, L Zhang - Expert Review of Clinical Immunology, 2023 - Taylor & Francis
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory
disease that is generally classified into type 2 and non-type 2 endotypes [1]. Type 2 …

Predictive markers of long-term recurrence in chronic rhinosinusitis with nasal polyps

D Rosati, C Rosato, G Pagliuca, B Cerbelli… - American journal of …, 2020 - Elsevier
Background In last years, many attempts were made to recognize chronic rhinosinusitis with
nasal polyps (CRSwNP) phenotypes focusing on identifying relevant key pathogenic …

Immunological profiling in chronic rhinosinusitis with nasal polyps reveals distinct VEGF and GM‐CSF signatures during symptomatic exacerbations

RD Divekar, S Samant, MA Rank… - Clinical & …, 2015 - Wiley Online Library
Background The mechanisms and immune pathways associated with chronic rhinosinusitis
(CRS) are not fully understood. Immunological changes during acute exacerbation of CRS …

[HTML][HTML] Identification of inflammatory endotypes by clinical characteristics and nasal secretion biomarkers in chronic rhinosinusitis with nasal polyps

CL Guo, RY Lu, CS Wang, JF Zhao, L Pan… - … Archives of Allergy and …, 2023 - karger.com
Introduction: The emergency of biologics and surgical techniques targeting the specific
inflammatory endotype in chronic rhinosinusitis with nasal polyps (CRSwNP) asks for …

Immunological profiling of key inflammatory drivers of nasal polyp formation and growth in chronic rhinosinusitis.

TC Biggs, SM Hayes, PG Harries, RN Allan, AF Walls… - Rhinology, 2019 - europepmc.org
Background Chronic rhinosinusitis (CRS) is a chronic inflammatory condition of the upper
airways, often associated with the formation of nasal polyps (CRSwNP). It is well established …

Endotypes of chronic rhinosinusitis with nasal polyps with and without NSAID-intolerance

UC Steiner, S Bischoff, A Valaperti, K Ikenberg… - Rhinology, 2020 - zora.uzh.ch
BACKGROUND Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2-dominated
inflammatory disease of the upper air-ways. A subgroup of patients with CRSwNP suffer …