Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …

Clonal hematopoiesis (CH), in which hematopoietic stem and progenitor cell (HSPC) clones
and their progeny expand in the circulating blood cell population, occurs following the …

Studies in recent years have revealed that increasing age is associated with the
accumulation of post-zygotic genetic aberrations in different cell lineages even in the …

Age is the most important risk factor for cardiovascular disease and appears to be more than
a marker of cumulative exposure to other risk factors such as dyslipidemia and hypertension …

Recent genomics studies have revealed that clonal hematopoietic expansion due to
recurrent somatic mutations in hematopoietic cells are common in older people without …

The accrual of somatic mutations is a byproduct of aging. When a clone bearing a somatic
genetic alteration, conferring comparative competitive advantage, displays sufficient …

Clonal hematopoiesis (CH) defines a population of hematopoietic cells with one or more
somatic mutations/copy number alterations that can expand with time and under positive …

Clonal haematopoiesis of indeterminate potential (CHIP) is widespread in the elderly. CHIP
is driven by somatic mutations in leukaemia driver genes, such as Janus Kinase 2 (JAK2) …

Abstract Purpose of Review This article summarizes the current knowledge about clonal
hematopoiesis of indeterminate potential (CHIP), its association with cardiovascular disease …

Recent genome‐wide studies have revealed that aging or chronic inflammation can cause
clonal expansion of cells in normal tissues. Clonal hematopoiesis has been the most …