New approaches beyond PD-1/PD-L1 inhibition are required to target the immunologically
diverse tumor microenvironment (TME) in high-grade serous ovarian cancer (HGSOC). In …

Abstract Background B7-H3 and B7-H4 are highly expressed by many human malignancies
making them attractive immunotherapeutic targets. However, their expression patterns and …

B7-H4 is a recently identified B7 family member. We previously showed that ovarian tumor
and associated macrophages expressed B7-H4; tumor B7-H4+ macrophages and CD4+ …

Tumor-associated macrophages are a prominent component of ovarian cancer stroma and
contribute to tumor progression. B7-H4 is a recently identified B7 family molecule. We show …

Abstract Although PD-L1/PD-1 blockade therapy has been approved to treat many types of
cancers, the majority of patients with solid tumors do not respond well, but the underlying …

Abstract B7-H3 and B7x are members of the B7 family of immune regulatory ligands that are
thought to attenuate peripheral immune responses through co-inhibition. Previous studies …

Introduction: It has been previously shown that B7-H4, one of the B7 family members that
serve as negative regulators of T cell function, has altered expression levels in a variety of …

A number of members of the B7 superfamily of ligands have been implicated in tumor
immunogenicity and cancer development. Two of these recently characterized ligands, B7 …

Within the ovarian cancer microenvironment, there are several mechanisms that suppress
the actions of antitumor immune effectors. Delineating the complex immune …

Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and are
associated with immune suppression. Here, we described high level of expression of B7-H1 …