Abstract Vitamin B12 (cobalamin, Cbl) is a cofactor for just two enzymes, while various forms
of folate are coenzymes for a wide range of enzymes. Metabolism of both vitamins involve …

Patients with inherited disorders affecting cobalamin (Cbl) absorption or metabolism show
elevations of homocysteine or methylmalonic acid, either alone or in combination. For those …

Abstract Cobalamin (Cbl, vitamin B 12) is a widely distributed, cobalt-containing, water-
soluble vitamin that is not found in higher plants. Cb1 is needed for only two reactions in …

This review highlights the features of cobalamin and folate deficiency and insufficiency that
are particular to children. Maternal deficiency of cobalamin and insufficiency or deficiency of …

Folate and cobalamin (vitamin B12) are B group vitamins that play interacting roles in
cellular metabolism. Hereditary folate malabsorption results in a specific deficiency of folate …

Deficient activity of an enzyme can result from a defect in the conversion of the vitamin to a
co-enzyme as well from an abnormal apo-enzyme or disturbed binding of co-enzyme to …

Folate and cobalamin are necessary for early brain development and function. Deficiency of
folate or cobalamin during pregnancy can cause severe malformation in the central nervous …

This review gives an overview of clinical characteristics, treatment and outcome of nutritional
and acquired cobalamin (Cbl; synonym: vitamin B12) deficiencies, inborn errors of Cbl …

Patients with disorders of intracellular Cbl metabolism typically have serum Cbl levels within
the reference range, although levels may be reduced in the cblF and cblJ disorders …

Vitamin B12 (Cbl) is needed for just two metabolic reactions in man, the methylation of
homocysteine to methionine (cofactor methyl-Cbl) and the conversion of methylmalonyl-CoA …