[HTML][HTML] Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies
D Pacheu-Grau, B Bareth, J Dudek, L Juris, FN Vögtle… - Cell metabolism, 2015 - cell.com
Three mitochondria-encoded subunits form the catalytic core of cytochrome c oxidase, the
terminal enzyme of the respiratory chain. COX1 and COX2 contain heme and copper redox …
terminal enzyme of the respiratory chain. COX1 and COX2 contain heme and copper redox …
[HTML][HTML] Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding
Cox17 is a key mitochondrial copper chaperone involved in the assembly of cytochrome c
oxidase (COX). The NMR solution structure of the oxidized apoCox17 isoform consists of a …
oxidase (COX). The NMR solution structure of the oxidized apoCox17 isoform consists of a …
Metal-binding mechanism of Cox17, a copper chaperone for cytochrome c oxidase
P Palumaa, L Kangur, A Voronova… - Biochemical …, 2004 - portlandpress.com
Cox17, a copper chaperone for cytochrome c oxidase, is an essential and highly conserved
protein. The structure and mechanism of functioning of Cox17 are unknown, and even its …
protein. The structure and mechanism of functioning of Cox17 are unknown, and even its …
[HTML][HTML] HIGD2A is required for assembly of the COX3 module of human mitochondrial complex IV
Assembly factors play a critical role in the biogenesis of mitochondrial respiratory chain
complexes I-IV where they assist in the membrane insertion of subunits, attachment of co …
complexes I-IV where they assist in the membrane insertion of subunits, attachment of co …
[HTML][HTML] Yeast Cox17 solution structure and copper (I) binding
C Abajian, LA Yatsunyk, BE Ramirez… - Journal of Biological …, 2004 - ASBMB
Cox17 is a 69-residue cysteine-rich, copper-binding protein that has been implicated in the
delivery of copper to the Cu A and Cu B centers of cytochrome c oxidase via the copper …
delivery of copper to the Cu A and Cu B centers of cytochrome c oxidase via the copper …
Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7
Nuclear and mitochondrial genome mutations lead to various mitochondrial diseases, many
of which affect the mitochondrial respiratory chain. The proteome of the intermembrane …
of which affect the mitochondrial respiratory chain. The proteome of the intermembrane …
A yeast suppressor screen links Coa4 to the mitochondrial copper delivery pathway for cytochrome c oxidase
Cytochrome c oxidase (CcO) is a multimeric copper-containing enzyme of the mitochondrial
respiratory chain that powers cellular energy production. The two core subunits of …
respiratory chain that powers cellular energy production. The two core subunits of …
Redox regulation of SCO protein function: controlling copper at a mitochondrial crossroad
SC Leary - Antioxidants & redox signaling, 2010 - liebertpub.com
Reversible changes in the redox state of cysteine residues represent an important
mechanism with which to regulate protein function. In mitochondria, such redox reactions …
mechanism with which to regulate protein function. In mitochondria, such redox reactions …
[HTML][HTML] A structural-dynamical characterization of human Cox17
Human Cox17 is a key mitochondrial copper chaperone responsible for supplying copper
ions, through the assistance of Sco1, Sco2, and Cox11, to cytochrome c oxidase, the …
ions, through the assistance of Sco1, Sco2, and Cox11, to cytochrome c oxidase, the …
Mitochondrial copper metabolism and delivery to cytochrome c oxidase
D Horn, A Barrientos - IUBMB life, 2008 - Wiley Online Library
Metals are essential elements of all living organisms. Among them, copper is required for a
multiplicity of functions including mitochondrial oxidative phosphorylation and protection …
multiplicity of functions including mitochondrial oxidative phosphorylation and protection …