Association of the interaction between mosaic chromosomal alterations and polygenic risk score with the risk of lung cancer: an array-based case-control association …
N Qin, C Wang, C Chen, L Yang, S Liu, J Xiang… - The Lancet …, 2022 - thelancet.com
Background Mosaic chromosomal alterations (mCAs) detected from blood-derived DNA are
large structural alterations of clonal haematopoietic origin and are associated with various …
large structural alterations of clonal haematopoietic origin and are associated with various …
Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations
J Dai, J Lv, M Zhu, Y Wang, N Qin, H Ma… - The Lancet …, 2019 - thelancet.com
Background Genetic variation has an important role in the development of non-small-cell
lung cancer (NSCLC). However, genetic factors for lung cancer have not been fully …
lung cancer (NSCLC). However, genetic factors for lung cancer have not been fully …
[HTML][HTML] Association of mosaic loss of chromosome Y with lung cancer risk and prognosis in a Chinese population
N Qin, N Li, C Wang, Z Pu, Z Ma, G Jin, M Zhu… - Journal of Thoracic …, 2019 - Elsevier
Introduction Mosaic loss of chromosome Y (mLOY) is the most commonly detectable mosaic
chromosomal event in cancers; however, its underlying relationship with tumorigenesis is …
chromosomal event in cancers; however, its underlying relationship with tumorigenesis is …
Ethnic differences of genetic risk and smoking in lung cancer: two prospective cohort studies
M Zhu, J Lv, Y Huang, H Ma, N Li, X Wei… - International journal …, 2023 - academic.oup.com
Background The role of genetic background underlying the disparity of relative risk of
smoking and lung cancer between European populations and East Asians remains unclear …
smoking and lung cancer between European populations and East Asians remains unclear …
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
MN Timofeeva, RJ Hung, T Rafnar… - Human molecular …, 2012 - academic.oup.com
Recent genome-wide association studies (GWASs) have identified common genetic variants
at 5p15. 33, 6p21–6p22 and 15q25. 1 associated with lung cancer risk. Several other …
at 5p15. 33, 6p21–6p22 and 15q25. 1 associated with lung cancer risk. Several other …
[HTML][HTML] Systematic analyses of genetic variants in chromatin interaction regions identified four novel lung cancer susceptibility loci
P Ji, D Ding, N Qin, C Wang, M Zhu, Y Li, J Dai… - Journal of …, 2020 - ncbi.nlm.nih.gov
Genome-wide association studies (GWAS) have reported 45 single-nucleotide
polymorphisms (SNPs) that may contribute to the susceptibility of lung cancer, with the …
polymorphisms (SNPs) that may contribute to the susceptibility of lung cancer, with the …
Combined analysis with copy number variation identifies risk loci in lung cancer
Background. Lung cancer is the most important cause of cancer mortality worldwide, but the
underlying mechanisms of this disease are not fully understood. Copy number variations …
underlying mechanisms of this disease are not fully understood. Copy number variations …
A rigorous and comprehensive validation: common genetic variations and lung cancer
P Yang, Y Li, R Jiang, JM Cunningham, F Zhang… - … , biomarkers & prevention, 2010 - AACR
Background: Multiple recent genome-wide studies of single nucleotide polymorphisms
(SNP) reported associations between candidate chromosome loci and lung cancer …
(SNP) reported associations between candidate chromosome loci and lung cancer …
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study
P Broderick, Y Wang, J Vijayakrishnan, A Matakidou… - Cancer research, 2009 - AACR
To explore the impact of common variation on the risk of developing lung cancer, we
conducted a two-phase genome-wide association (GWA) study. In phase 1, we compared …
conducted a two-phase genome-wide association (GWA) study. In phase 1, we compared …
Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women
Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women
have previously identified six susceptibility loci associated with lung cancer risk. To further …
have previously identified six susceptibility loci associated with lung cancer risk. To further …
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