Platelets are important in acute thrombotic occlusion of injured vessels, eg, subsequent to
angioplasty. In contrast to these acute events of thrombus formation, much less is known …

Smooth muscle cell (SMC) proliferation is a key event in atherosclerosis and in the
restenosis of arteries after angioplasty. We and colleagues in many other laboratories have …

Publisher Summary The proliferation of smooth muscle cells is thought to be a key event in
the development of atherosclerotic lesions and is involved in the restenosis of arteries. To …

A growth-promoting activity released from activated platelets, the platelet-derived growth
factor, was discovered and characterized while the cellular and molecular mechanisms …

Background: Previous studies indicate that platelets and leucocytes might contribute to the
development of neointimal hyperplasia following arterial injury. The present study was …

In previous experiments (Grotendorst et al, 1981), we showed that platelet-derived growth
factor promotes the migration of smooth muscle cells in vitro. Using a “checkerboard” …

Release of platelet-derived growth factor (PDGF) from platelets has been postulated to
stimulate at least some of the cell proliferation seen at sites of tissue damage, both …

Blood platelets play a predominant role in arterial thrombosis. This has long been
recognized by pathologists. However, only recently the pathophysiologic prerequisites …

Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth
muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused …

The smooth muscle cells (SMC) of the blood vessel wall are normally present in a relatively
quiescent stale. However, arterial injury or vascular disease induces a proliferative response …