Nicotine versus 6-hydroxy-l-nicotine against chlorisondamine induced memory impairment and oxidative stress in the rat hippocampus

L Hritcu, R Ionita, DE Motei, C Babii, M Stefan… - Biomedicine & …, 2017 - Elsevier
Hydroxy-l-nicotine (6HLN), a nicotine derivative from nicotine degradation by Arthrobacter
nicotinovorans pAO1 strain was found to improve behavioral deficits and to reverse …

Enhanced behavioral response by decreasing brain oxidative stress to 6-hydroxy-l-nicotine in Alzheimer's disease rat model

L Hritcu, M Stefan, R Brandsch, M Mihasan - Neuroscience Letters, 2015 - Elsevier
Hydroxy-l-nicotine (6HLN) is a nicotine metabolite resulted from nicotine degradation within
Arthrobacter nicotinovorans with positive effects on spatial memory and oxidative stress …

6-hydroxy-l-nicotine from Arthrobacter nicotinovorans sustain spatial memory formation by decreasing brain oxidative stress in rats

L Hritcu, M Stefan, R Brandsch, M Mihasan - Journal of physiology and …, 2013 - Springer
Male Wistar rats were subjected to chronic 6-hydroxy-l-nicotine treatment (6HLN, 0.3 mg/kg,
ip, seven consecutive days) and their memory performance was studied by means of Y …

[PDF][PDF] 6-Hydroxy-l-nicotine effects on anxiety and depression in a rat model of chlorisondamine

R Ioniță, VM Valu, PA Postu, O Cioancă, L Hrițcu… - …, 2017 - farmaciajournal.com
Studii recente au demonstrat că 6-hidroxi-L-nicotina (6HLN), un derivat al nicotinei rezultat
prin degradarea acesteia de către Arthrobacter nicotinovorans pAO1, a îmbunătățit …

[HTML][HTML] Cotinine and 6-Hydroxy-L-Nicotine Reverses Memory Deficits and Reduces Oxidative Stress in Aβ25-35-Induced Rat Model of Alzheimer's Disease

RS Boiangiu, M Mihasan, DL Gorgan, BA Stache… - Antioxidants, 2020 - mdpi.com
The nicotinic derivatives, cotinine (COT), and 6-hydroxy-L-nicotine (6HLN), showed
promising cognitive-improving effects without exhibiting the nicotine's side-effects. Here, we …

The benefits and drawbacks of nicotine exposure in the cortex and hippocampus of old rats

DM Barros, FG Galhardi, JLR Ferreira, LB Guterres… - Neurotoxicology, 2007 - Elsevier
Nicotine is the main alkaloid of tobacco and possesses well-established stimulant effects.
Previous reports show that nicotine at low doses improves memory functions, while high …

Neuroactive effects of cotinine on the hippocampus: behavioral and biochemical parameters

RB De Aguiar, GM Parfitt, J Jaboinski, DM Barros - Neuropharmacology, 2013 - Elsevier
The present work evaluated the effects of nicotine (NIC), cotinine (COT), mecamylamine
(MEC), methyllycaconitine (MLA) and dihydro-beta-eritroidine (DHβE) on memory extinction …

Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice

SH Kwon, HK Lee, JA Kim, SI Hong, HC Kim… - European journal of …, 2010 - Elsevier
Chlorogenic acid is a major polyphenolic component of many plants and beverages, and is
particularly abundant in coffee. We evaluated the neuroprotective effects of chlorogenic acid …

Nicotine-induced memory impairment by increasing brain oxidative stress

L Hritcu, A Ciobica, L Gorgan - Central European journal of biology, 2009 - Springer
Male Wistar rats were subjected to chronic nicotine treatment (0.3 mg/kg; 7 continuous days)
and their memory performance was studied by means of Y-maze and multi-trial passive …

Non-steroidal anti-inflammatory agents, tolmetin and sulindac attenuate quinolinic acid (QA)-induced oxidative stress in primary hippocampal neurons and reduce QA …

A Dairam, AC Müller, S Daya - Life sciences, 2007 - Elsevier
Accumulating evidence suggests that anti-inflammatory agents and antioxidants have
neuroprotective properties and may be beneficial in the treatment of neurodegenerative …