Utricular hair cells (HCs) are mechanoreceptors required for vestibular function. After
damage, regeneration of mammalian utricular HCs is limited and regenerated HCs appear …

Loss of vestibular hair cells is a common cause of balance disorders. Current treatment
options for bilateral vestibular dysfunction are limited. During development, atonal homolog …

In amniotes, head movements are encoded by two types of vestibular hair cells (type I and
type II) with unique morphology, physiology, and innervation. After hair cell destruction in …

Sensory hair cells (HCs) in the utricle are mechanoreceptors required to detect linear
acceleration. After damage, the mammalian utricle partially restores the HC population and …

Herein, we will review molecular aspects of vestibular ear development and present them in
the context of evolutionary changes and hair cell regeneration. Several genes guide the …

Hair cells regenerate throughout the lifetime of non-mammalian vertebrates, allowing these
animals to recover from hearing and balance deficits. Such regeneration does not occur …

Aging, disease, and trauma can lead to loss of vestibular hair cells and permanent vestibular
dysfunction. Previous work showed that, following acute destruction of∼ 95% of vestibular …

The mammalian cochlea loses its ability to regenerate new hair cells prior to the onset of
hearing. In contrast, the adult vestibular system can produce new hair cells in response to …

Human vestibular sensory epithelia in explant culture were incubated in gentamicin to
ablate hair cells. Subsequent transduction of supporting cells with ATOH1 using an Ad-2 …

Vestibular hair cells in the inner ear encode head movements and mediate the sense of
balance. These cells undergo cell death and replacement (turnover) throughout life in non …