The acute phase of Chagas disease (CD) is characterized by high parasitic proliferation and
intense inflammation, exacerbating the generation of reactive oxygen species (ROS) and …

Chagas disease (CD) is one of the most important neglected tropical diseases in the
American continent. Host‐derived nitroxidative stress in response to Trypanosoma cruzi …

Trypanosoma cruzi infection stimulates inflammatory mediators which cause oxidative
stress, and the use of antioxidants can minimize the sequelae of Chagas disease. In order to …

ABSTRACT A nutritional characteristic of trypanosomatid protozoa is that they need a heme
compound as a growth factor. Because of the cytotoxic activity of heme and its structural …

Background Drugs currently used for the treatment of Chagas' disease, nifurtimox and
benznidazole, have a limited effectiveness and toxic side effects. With the aim of finding new …

Although curcumin can increase the effectiveness of drugs against malaria, combination
therapies using the molecule have never been investigated in Chagas disease (ChD) …

Chagas disease is an important public health problem in Latin America, and its treatment by
chemotherapy with benznidazole (BZ) or nifurtimox remains unsatisfactory. In order to …

Chagas' disease (CD) is caused by the protozoan Trypanosoma cruzi (Tc) and remains an
important cause of morbidity and mortality. Most researchers in the field now agree that …

Chagas disease is a neglected tropical disease caused by the flagellated protozoa
Trypanosome cruzi. This illness affects to almost 8–12 million people worldwide, however, is …

The nitroheterocyclic drugs nifurtimox and benznidazole are first-line drugs available to treat
Chagas disease; however, they have limitations, including long treatment courses and …