Background Sex‐related differences in cardiac function and iron metabolism exist in
humans and experimental animals. Male patients and preclinical animal models are more …

Iron cardiomyopathy is the leading cause of death in transfusional iron overload, and men
have twice the mortality of women. Because the prevalence of cardiac iron overload …

Iron-overload cardiomyopathy is prevalent on a worldwide basis and is a major comorbidity
in patients with genetic hemochromatosis and secondary iron overload. Therapies are …

Iron plays a crucial role in a large number of physiological functions:(1) oxygen transport as
a component of hemoglobin and myoglobin,(2) oxidative phosphorylation as a component of …

Iron-overload cardiomyopathy is a restrictive cardiomyopathy that manifests itself as systolic
or diastolic dysfunction secondary to increased deposition of iron in the heart and occurs …

Cardiac damage associated with iron overload is the most common cause of morbidity and
mortality in patients with hereditary hemochromatosis, but the precise mechanisms leading …

Iron-overload cardiomyopathy is a prevalent cause of heart failure on a world-wide basis
and is a major cause of mortality and morbidity in patients with secondary iron-overload and …

Hereditary hemochromatosis is an inherited pathological condition characterized by iron
overload in several vital organs including heart. To increase our understanding of the …

Background Up to 50% of patients with chronic heart failure (HF) have systemic iron
deficiency, which contributes to symptoms and poor prognosis. Myocardial iron deficiency …

Iron overload cardiomyopathy (IOC), defined as the presence of systolic or diastolic cardiac
dysfunction secondary to increased deposition of iron, is emerging as an important cause of …