Low aqueous solubility and thereby low oral bioavailability is a major concern for
formulation scientist as many recent drugs are lipophillic in nature and their lower solubility …

More than 60% of drugs have lipophilic nature and exhibit poor water-solubility. The
dissolution is the rate limiting step in their absorption and oral bioavailability. To overcome …

Oral route is preferred for drug administration. More than 40% of New Chemical Entities
exhibit poor aqueous solubility resulting in unsatisfactory oral drug delivery. Low aqueous …

Drugs are most often administered by the oral route. However, more than 40% of new
chemical entities exhibit poor aqueous solubility, resulting in unsatisfactory oral drug …

Self-emulsifying drug delivery systems (SEDDS) are one of the proven methods to increase
solubility and bioavailability of poorly soluble drugs. SEDDS are isotropic mixtures …

The main objective of drug (s) formulation is to enhance the bioavailability of the drug within
the body. Some of the challenging issues associated with poorly water-soluble drugs …

Sažetak Low oral bioavailability as a consequence of low water solubility of drugs is a
growing challenge to the development of new pharmaceutical products. One of the most …

Oral route is most common route of drug administration and it is the first way investigated in
the development of new dosage forms. In oral drug formulations major problem arises is the …

Background High lipophilicity and poor aqueous solubility are the endemic problems of new
drug molecules. Sixty to seventy percent of these drugs are unable to solubilize completely …

ABSTRACT Around 40-60% of potential drugs in the pharmaceutical market are lipophilic in
nature due to the low aqueous solubility and low permeability and thereby facing problems …