The immune system is a vital determinant of cancer and shapes its trajectory. Notably, the
immune reaction to cancer harbors dual potential for suppressing or promoting cancer …

The immune system plays a dual role in cancer. It conveys protective immunity but also
facilitates malignant progression, either by sculpting tumor immunogenicity or by creating a …

The innate immune system has evolved in multicellular organisms to detect and respond to
situations that compromise tissue homeostasis. It comprises a set of tissue-resident and …

Innate lymphoid cells (ILCs) are increasingly appreciated as important participants in
homeostasis and inflammation. Substantial plasticity and heterogeneity among ILC …

Innate lymphoid cells (ILCs) are a family of innate immune cells that have diverse functions
during homeostasis and disease. Subsets of ILCs have phenotypes that mirror those of …

Highlights•Cytotoxic ILCs are marked by the expression of CD127 and CD94 and absence
of mature NK cell markers.•Cytotoxic ILC1s and ILC3s have a similar genetic profile to their …

Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are populations of non-T,
non-B lymphocytes in peripheral tissues. Although NK and ILC1 subsets have been …

Although the function of the circulating immune cell compartment has been studied in detail
for decades, limitations in terms of access and cell yields from peripheral tissues have …

Type I innate lymphoid cells (ILC1s) are critical regulators of inflammation and immunity in
mammalian tissues. However, their function in cancer is mostly undefined. Here, we show …

One of the primary goals in tumor immunotherapy is to reset the immune system from
tolerogenic to immunogenic–a process in which invariant natural killer T (iNKT) cells are …