The influence of β-cyclodextrin on the physicochemical properties of bendrofluazide,
chlorothiazide, hydrochlorothiazide and hydroflumethiazide was investigated using …

Solubility enhancement has broad implications in parenteral formulation design. A simple
mathematical model has been developed to describe the combined effect of cosolvency and …

The most common stoichiometry of drug/cyclodextrin complexes is 1: 1, ie one drug
molecule forms a complex with one cyclodextrin molecule, and the most common method for …

The effect of 2-hydroxypropyl-B-cyclodextrin (HPBCD) on the aqueous solubility of 13 drugs
was investi-gated. In general, the largest solubility enhancement was obtained for apolar …

Cyclodextrins are popular drug solubilizers, but the use of the natural cyclodextrins is
hampered by their tendency to coprecipitate with the drug. To understand and overcome …

In this study, β-CD was evaluated as a direct compression vehicle either singly or in blends
with spray-dried lactose (sp. dl) for preparing tablets containing either phenobarbitone …

Cyclodextrins are cyclic oligosaccharides which have recently been recognized as useful
pharmaceutical excipients. The molecular structure of these glucose derivatives, which …

Cyclodextrins have gained currency as useful solubilizing excipients with an ever increasing
list of beneficial properties and functionalities. Although their use in liquid dosage forms …

Phase‐solubility diagrams are frequently used to calculate stoichiometry of drug/cyclodextrin
complexes. Linear diagrams (AL‐type systems) are thought to indicate that the complexes …

The purpose of this study was to increase the solubility of furosemide (FR) with inclusion
compound of β-cyclodextrin (β-CD). The interaction between FR and β-CD in solution was …