Patterned surfaces direct cell spatial dynamics, yielding cells oriented along the surface
geometry, in a process known as contact guidance. The Rho family of GTPases controls the …

Topographical and chemical features of biomaterial surfaces affect the cell physiology at the
interface and are promising tools for the improvement of implants. The dominance of the …

Surface topography broadly influences cellular responses. Adherent cell activities are
regulated, in part, by RhoA, a member of the Rho‐family of GTPases. In this study, we …

While topography is a key determinant of the cellular response to biomaterials, the
mechanisms implicated in the cell-surface interactions are complex and still not fully …

Surface topography affects cell function and differentiation. It has been previously shown
that rough surfaces can enhance the activation of canonical Wnt signaling, an important …

The role of micrometer and submicrometer surface roughness on the interaction of cells with
titanium model surfaces of well-defined topography was investigated using human bone …

Osteoblast reactions to topographic structures of titanium play a key role in host tissue
responses and the final osseointegration. Since it is difficult to fabricate micro-and nano …

Abstract Titanium (Ti) and Ti alloys are used in orthopaedic/spine applications where
biological implant fixation, or osseointegration, is required for long-term stability. These …

Surface roughness affects various cell activities, including osteoblast motility, which may
have an effect on bone regeneration. Defective cell signaling, which is associated with the …

The differentiation of progenitor cells is dependent on more than biochemical signalling.
Topographical cues in natural bone extracellular matrix guide cellular differentiation through …