Although hematopoietic stem cells (HSCs) have traditionally been thought to possess the
ability to give rise to all the mature cell types in the hematopoietic system, this conception of …

Ageing is a major risk factor for the development of cardiovascular disease (CVD) and
cancer. Whilst the cumulative effect of exposure to conventional cardiovascular risk factors is …

Abstract Clonal hematopoiesis (CH)—age-related expansion of mutated hematopoietic
clones—can differ in frequency and cellular fitness by CH type (eg, mutations in driver genes …

Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-
associated genes, commonly occurs among aging human hematopoietic stem cells. We …

BACKGROUND Somatic mutations accumulate in normal tissues as a function of time. The
great majority of these mutations have no effect on fitness, so selection does not act upon …

Clonal hematopoiesis results from enhanced fitness of a mutant hematopoietic stem and
progenitor cell (HSPC), but how such clones expand is unclear. We developed a technique …

Simple Summary The development of blood cancers is a complex process that involves the
acquisition of specific blood disorders that precede cancer. These blood disorders are often …

Clonal haematopoiesis of indeterminate potential (CHIP) is a preclinical condition wherein a
sizeable proportion of an individual's circulating blood cells are derived from a single …

Abstract Purpose of Review The hematopoietic stem cell (HSC) compartment is the
cornerstone of a lifelong blood cell production but also contributes to the ability of the …

Recent advances have highlighted the ability of hematopoietic stem and progenitor cells in
the bone marrow to sense peripheral inflammation or infection and adapt through increased …