Effect of losartan, an AT1 selective angiotensin II receptor antagonist, on isoproterenol-induced cardiac ornithine decarboxylase activity.
M Nakano, T Kanda, S Matsuzaki… - Research …, 1995 - europepmc.org
Ornithine decarboxylase (ODC, EC 4.1. 1.7), a rate-limiting enzyme in polyamine
biosynthesis, is known to be induced by a beta-adrenoceptor agonist, isoproterenol (ISO) …
biosynthesis, is known to be induced by a beta-adrenoceptor agonist, isoproterenol (ISO) …
Effect of captopril on isoproterenol-induced myocardial ornithine decarboxylase activity
M Shimizu, O Irimajiri, T Nakano, T Mizokami… - Journal of molecular and …, 1991 - Elsevier
Polyamines are thought to play an essential role in cellular hypertrophy and proliferation.
Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in …
Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in …
The induction of cardiac ornithine decarboxylase by β2‐adrenergic agents is associated with calcium channels and phosphorylation of ERK1/2
AJ López‐Contreras, ME de la Morena… - Journal of Cellular …, 2013 - Wiley Online Library
The role that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in
polyamine biosynthesis, by beta‐adrenergic agents may have in heart hypertrophy is a …
polyamine biosynthesis, by beta‐adrenergic agents may have in heart hypertrophy is a …
Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy
E Giordano, RA Hillary, TC Vary, AE Pegg, AD Sumner… - Amino Acids, 2012 - Springer
Ornithine decarboxylase (ODC), the first enzyme of polyamine metabolism, is rapidly
upregulated in response to agents that induce a pathological cardiac hypertrophy …
upregulated in response to agents that induce a pathological cardiac hypertrophy …
beta 2-Adrenoceptors regulate induction of myocardial ornithine decarboxylase in mice in vivo.
JG Copeland, DF Larson, WR Roeske… - British Journal of …, 1982 - ncbi.nlm.nih.gov
The pharmacological characteristics of the myocardial adrenoceptor of the mouse have
been examined during embryogenesis by measuring ornithine decarboxylase (ODC, EC …
been examined during embryogenesis by measuring ornithine decarboxylase (ODC, EC …
Isoprenaline induced changes in ornithine decarboxylase activity and polyamine content in regions of the rat heart
UR TIPNIS, K FRASIER-SCOTT… - Cardiovascular …, 1989 - academic.oup.com
Isoprenaline stimulated increases in ornithine decarboxylase activity and polyamine content
in cardiac tissues are implicated in macromolecular synthesis and cellular growth, but little is …
in cardiac tissues are implicated in macromolecular synthesis and cellular growth, but little is …
Stimulation of rat heart ornithine decarboxylase by isoproterenol: evidence for post-translational control of enzyme activity?
C Lau, TA Slotkin - European Journal of Pharmacology, 1982 - Elsevier
The activity of rat heart ornithine decarboxylase (ODC), the enzyme involved in the initial
step of polyamine biosynthesis, was markedly stimulated after isoproterenol treatment …
step of polyamine biosynthesis, was markedly stimulated after isoproterenol treatment …
Targeted overexpression of ornithine decarboxylase enhances β-adrenergic agonist-induced cardiac hypertrophy
LM SHANTZ, DJ FEITH, AE PEGG - Biochemical Journal, 2001 - portlandpress.com
These studies were designed to determine the consequences of constitutive overexpression
of ornithine decarboxylase (ODC) in the heart. Induction of ODC is known to occur in …
of ornithine decarboxylase (ODC) in the heart. Induction of ODC is known to occur in …
Ornithine decarboxylase in cardiac hypertrophy in the rat
S Matsushita, RK Sogani, MS Raben - Circulation Research, 1972 - Am Heart Assoc
Ornithine decarboxylase, a possible rate-limiting enzyme in the synthesis of polyamines,
was assayed in hearts of normal rats, sham-operated rats, and rats subjected to aortic …
was assayed in hearts of normal rats, sham-operated rats, and rats subjected to aortic …
Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase
JV Bartolome, PA Trepanier, EA Chait… - Journal of Molecular and …, 1982 - Elsevier
DFMO is a selective irreversible inhibitor of ornithine decarboxylase (ODC), the initial
enzyme in the polyamine biosynthetic pathway. DFMO was utilized to determine the role of …
enzyme in the polyamine biosynthetic pathway. DFMO was utilized to determine the role of …