Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli

C LAU, TA SLOTKIN - Molecular Pharmacology, 1979 - ASPET
The activity of ornithine decarboxylase (ODC), the rate-limiting enzyme involved in the
biosynthesis of polyamines, is markedly elevated in the adult rat heart 4 hr after …

Effect of stress and sympathetic activity on rat cardiac and aortic ornithine decarboxylase activity

PV Thadani, SM Schanberg - Life Sciences, 1979 - Elsevier
Adult male rats were injected either with α-or ß-adrenergic agonists and/or antagonists and
ornithine decarboxylase (ODC) activity in the heart and aorta was measured 4 hours later. At …

Studies of noradrenergic influence on cardiac ornithine decarboxylase in rats

RW Fuller, SK Hemrick - Journal of Molecular and Cellular Cardiology, 1978 - Elsevier
Ornithine decarboxylase activity in rat heart was increased significantly by the injection of l-
norepinephrine or nisoxetine, an inhibitor of norepinephrine uptake. The enzyme was also …

Early alterations of polyamine metabolism induced after acute administration of clenbuterol in mouse heart

JC Cubria, C Ordonez, RM Reguera, BL Tekwani… - Life sciences, 1999 - Elsevier
An acute treatment of mice with clenbuterol, a β-adrenergic agonist, produced a marked
increase of polyamines levels in heart, particularly during the early phase of administration …

Regulation of ornithine decarboxylase activity in the developing heart of euthyroid or hyperthyroid rats

C LAU, TA SLOTKIN - Molecular Pharmacology, 1980 - ASPET
Ornithine decarboxylase (ODC), the rate-limiting enzyme in the biosynthesis of polyamines,
displays high activity early in postnatal development of the heart, followed by a gradual …

Cooperative action of insulin and catecholamines on stimulation of ornithine decarboxylase activity in neonatal rat heart cells

M Roraason, ME Luken, JA Krueger - Journal of molecular and cellular …, 1990 - Elsevier
Stimulation of ornithine decarboxylase (ODC) activity was examined in cultured heart cells
from neonatal rats. Fetal bovine serum had a concentration-dependent effect on ODC …

Central role for ornithine decarboxylase in β-adrenoceptor mediated hypertrophy

KD Schlüter, K Frischkopf, M Flesch… - Cardiovascular …, 2000 - academic.oup.com
Objective: TGF-β stimulation of cardiac myocytes induces a hypertrophic responsiveness to
β-adrenoceptor stimulation. This study investigates whether this β-adrenoceptor mediated …

[PDF][PDF] Ontogeny of cardiac ornithine decarboxylase and its beta adrenergic responsiveness in the rat.

SP Miska, GL Kimmel, JR Harmon, P Webb - Journal of Pharmacology and …, 1984 - Citeseer
Ornithine decarboxylase(ODC) is a marker of tissue growth and development and, because
sympathetic stimulation of beta adrenergic receptors acutely increases ODC in the adult rat …

Heart ornithine decarboxylase from control and isoproterenol-treated rats: kinetic properties, multiple forms and subcellular distribution.

F Flamigni, C Guarnieri, CM Caldarera - General Pharmacology, 1986 - europepmc.org
Heart ornithine decarboxylase (ODC) from isoproterenol treated rats was compared to heart
ODC from control rats. Isoproterenol administration did not significantly change Km for …

Responses of heart ornithine decarboxylase and adrenal catecholamines to methadone and sympathetic stimulants in developing and adults rats.

DL Bareis, TA Slotkin - Journal of Pharmacology and Experimental …, 1978 - ASPET
Sympathetic stimulation elevates heart ornithine decarboxylase (ODC) activity in adult rats,
an effect which is followed by cardiac hypertrophy. In developing animals, adrenergic …