Most nonuterine high-grade serous carcinomas (HGSCs) in women with hereditary breast
and ovarian cancer syndrome, due to germline BRCA1/2 mutation, arise in the fimbria of the …

Objectives The natural history and optimal management of serous tubal intraepithelial
carcinoma (STIC), regardless of BRCA status, is unknown. We report the follow-up findings …

Accumulating recent evidence suggests that the majority of extrauterine high-grade serous
carcinomas (HGSCs) do not arise from the ovary as historically accepted but from the distal …

Early detection of sporadic pelvic serous carcinoma remains an elusive goal. In women at
high risk for hereditary breast and ovarian cancer syndrome who undergo prophylactic …

Most early adnexal carcinomas detected in asymptomatic women with germline BRCA
mutations (BRCA+) present as serous tubal intraepithelial carcinomas (STIC). However …

Serous tubal intraepithelial carcinoma (STIC) has been implicated in the pathogenesis of
pelvic serous carcinoma. We hypothesized that, if this is the case, the frequency of STIC …

We investigated the frequency, histopathologic, and immunohistochemical characteristics of
tubal involvement in uterine serous carcinoma (USC) and aimed to clarify the relationship …

A precursor for invasive ovarian/pelvic high-grade serous carcinoma, termed serous tubal
intraepithelial carcinoma (STIC), has been identified and characterized through careful …

INTRODUCTION: Serous carcinomas are the most frequent histologic type of ovarian and
peritoneal cancers, and can also be detected in the endometrium and fallopian tubes …

Recent data suggest that intraepithelial carcinoma of the fallopian tube [serous tubal
intraepithelial carcinoma (STIC)] is the precursor of high-grade extrauterine serous …