Natural killer cells in cancer biology and therapy

SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …

Therapeutic potential and challenges of natural killer cells in treatment of solid tumors

A Gras Navarro, AT Björklund, M Chekenya - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …

Natural killer cells and solid tumors

A Stojanovic, A Cerwenka - Journal of innate immunity, 2011 - karger.com
Natural killer (NK) cells play an important role in the innate immune response against
cancer, in particular in the elimination of tumor metastases and small tumors. NK cell …

Natural killer cell-based therapies targeting cancer: possible strategies to gain and sustain anti-tumor activity

CIM Dahlberg, D Sarhan, M Chrobok, AD Duru… - Frontiers in …, 2015 - frontiersin.org
Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …

Natural killer cells: diverse functions in tumor immunity and defects in pre-neoplastic and neoplastic stages of tumorigenesis

A Jewett, J Kos, K Kaur, T Safaei, C Sutanto… - Molecular Therapy …, 2020 - cell.com
Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …

Targeting natural killer cells in solid tumors

G Habif, A Crinier, P André, E Vivier… - Cellular & molecular …, 2019 - nature.com
Natural killer (NK) cells are innate lymphoid cells endowed with cytolytic activity and a
capacity to secrete cytokines and chemokines. Several lines of evidence suggest that NK …

Targeting natural killer cells and natural killer T cells in cancer

E Vivier, S Ugolini, D Blaise, C Chabannon… - Nature Reviews …, 2012 - nature.com
Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …

Natural killer cells: a review of biology, therapeutic potential and challenges in treatment of solid tumors

K Choucair, JR Duff, CS Cassidy, MT Albrethsen… - Future …, 2019 - Taylor & Francis
Natural killer (NK) cells lead immune surveillance against cancer and early elimination of
small tumors. Owing to their ability to engage tumor targets without the need of specific …

Natural killer cell‐based immunotherapy in cancer: current insights and future prospects

T Sutlu, E Alici - Journal of internal medicine, 2009 - Wiley Online Library
As our understanding of the molecular mechanisms governing natural killer (NK) cell activity
increases, their potential in cancer immunotherapy is growing increasingly prominent. This …

The molecular mechanism of natural killer cells function and its importance in cancer immunotherapy

S Paul, G Lal - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …