Several drugs that are applied directly to the inner ear are in widespread clinical use for the
treatment of inner-ear disorders. Many new substances and drug delivery systems specific to …

Numerous disease processes cause inner ear dysfunction and represent an opportunity for
therapeutic intervention. Hearing loss is the common endpoint of many inner ear disorders …

Abstract Objective/Hypothesis: Previous studies revealed that intratympanic administration
of the steroid dexamethasone in poloxamer 407 hydrogel, a class of thermoreversible …

Local drug delivery to the ear has gained wide clinical acceptance, with the choice of drug
and application protocol in humans largely empirically-derived. Here, we review the …

Progress in drug delivery to the ear has been achieved over the last few years. This review
illustrates the main mechanisms of controlled drug release and the resulting geometry-and …

The inner ear is exposed to aminoglycosides or other drugs either intentionally or as a side
effect of clinical treatments directed at other regions of the body. An understanding of the …

Many inner ear disorders cannot be adequately treated by systemic drug delivery. A blood-
cochlear barrier exists, similar physiologically to the blood-brain barrier, which limits the …

Local, rather than systemic, drug delivery to the inner ear is becoming more widely used to
treat inner ear disorders. While many substances are undergoing preclinical and clinical …

Scientists and clinicians who are interested in the auditory system in general, and in the
diagnosis and treatment of inner ear disorders have long been studying the anatomical and …

Introduction: Diseases of the inner ear include those of the auditory and vestibular systems,
and frequently result in disabling hearing loss or vertigo. Despite a rapidly expanding …