lncRNA XLOC013218 promotes cell proliferation and TMZ resistance by targeting the PIK3R2‐mediated PI3K/AKT pathway in glioma

J Zhou, N Xu, B Liu, C Wang, Z He, C Lenahan… - Cancer …, 2022 - Wiley Online Library
The discovery of long noncoding RNAs (lncRNAs) has improved the understanding of
development and progression in various cancer subtypes. However, the role of lncRNAs in …

Long noncoding RNA KCNQ1OT1 confers gliomas resistance to temozolomide and enhances cell growth by retrieving PIM1 from miR-761

W Wang, S Han, W Gao, Y Feng, K Li, D Wu - Cellular and Molecular …, 2022 - Springer
Many studies have found that the dysregulation of long noncoding RNA (lncRNA)
contributed to cancer initiation, progression, and recurrence via multiple signaling pathways …

Long noncoding RNA AC003092. 1 promotes temozolomide chemosensitivity through miR-195/TFPI-2 signaling modulation in glioblastoma

N Xu, B Liu, C Lian, DM Doycheva, Z Fu, Y Liu… - Cell death & …, 2018 - nature.com
Temozolomide (TMZ) and radiation therapy combination for glioblastoma (GB) patients has
been considered as the most effective therapy after surgical procedure. However, the overall …

[HTML][HTML] Long noncoding RNA RP11-838N2. 4 enhances the cytotoxic effects of temozolomide by inhibiting the functions of miR-10a in glioblastoma cell lines

Y Liu, N Xu, B Liu, Y Huang, H Zeng, Z Yang, Z He… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Resistance to temolozomide (TMZ), the standard chemotherapy agent for treating
glioblastomas (GBM), is a major clinical problem for patients with GBM. Recently, long …

LINC00174 down-regulation decreases chemoresistance to temozolomide in human glioma cells by regulating miR-138-5p/SOX9 axis

B Li, H Zhao, J Song, F Wang, M Chen - Human Cell, 2020 - Springer
Temozolomide (TMZ) is one of the most common drugs selected for glioma chemotherapy,
but the therapeutic effect of glioma treatment is usually limited due to its resistance. Long …

Long non-coding RNA in glioma: novel genetic players in temozolomide resistance

J Roh, M Im, JH Kang, BH Youn… - Animal Cells and Systems, 2023 - Taylor & Francis
Glioma is the most common primary malignant brain tumor in adults and accounts for
approximately 80% of brain and central nervous system tumors. In 2021, the World Health …

LncRNA SOX2OT promotes temozolomide resistance by elevating SOX2 expression via ALKBH5-mediated epigenetic regulation in glioblastoma

B Liu, J Zhou, C Wang, Y Chi, Q Wei, Z Fu, C Lian… - Cell death & …, 2020 - nature.com
Temozolomide (TMZ) resistance is a major cause of recurrence and poor prognosis in
glioblastoma (GBM). Recently, increasing evidences suggested that long noncoding RNAs …

Silencing lncRNA LINC01410 suppresses cell viability yet promotes apoptosis and sensitivity to temozolomide in glioblastoma cells by inactivating PTEN/AKT …

T Fu, Y Yang, Z Mu, R Sun, X Li… - Immunopharmacology …, 2021 - Taylor & Francis
Abstract Background Long non-coding RNAs (LncRNAs) are involved in glioblastoma
(GBM), but the role of long intergenic non-protein coding RNA 01410 (lncRNA LINC01410) …

LINC00511 facilitates Temozolomide resistance of glioblastoma cells via sponging miR‐126‐5p and activating Wnt/β‐catenin signaling

Y Lu, M Tian, J Liu, K Wang - Journal of Biochemical and …, 2021 - Wiley Online Library
Temozolomide (TMZ) is the first‐line chemotherapy drug for glioblastoma (GBM) but
acquired TMZ resistance is frequently observed. Thus, a TMZ resistant GBM cell line U87‐R …

The roles played by long non-coding RNAs in glioma resistance

Y Chae, J Roh, W Kim - International journal of molecular sciences, 2021 - mdpi.com
Glioma originates in the central nervous system and is classified based on both histological
features and molecular genetic characteristics. Long non-coding RNAs (lncRNAs) are …