The roles of optogenetics and technology in neurobiology: a review

W Chen, C Li, W Liang, Y Li, Z Zou, Y Xie… - Frontiers in Aging …, 2022 - frontiersin.org
Optogenetic is a technique that combines optics and genetics to control specific neurons.
This technique usually uses adenoviruses that encode photosensitive protein. The …

New era of optogenetics: from the central to peripheral nervous system

X Xu, T Mee, X Jia - Critical reviews in biochemistry and molecular …, 2020 - Taylor & Francis
Optogenetics has recently gained recognition as a biological technique to control the activity
of cells using light stimulation. Many studies have applied optogenetics to cell lines in the …

Optogenetics in brain research: from a strategy to investigate physiological function to a therapeutic tool

E Montagni, F Resta, ALA Mascaro, FS Pavone - Photonics, 2019 - mdpi.com
Dissecting the functional roles of neuronal circuits and their interaction is a crucial step in
basic neuroscience and in all the biomedical field. Optogenetics is well-suited to this …

Taking optogenetics into the human brain: opportunities and challenges in clinical trial design

M White, M Mackay, RG Whittaker - Open access journal of clinical …, 2020 - Taylor & Francis
Optogenetics, the use of light to control the activity of suitably sensitized cells, has led to
major advances in the field of basic neuroscience since it first emerged in 2005. Already, the …

Optogenetics, tools and applications in neurobiology

P Mahmoudi, H Veladi, FG Pakdel - Journal of Medical Signals & …, 2017 - journals.lww.com
Comprehension of the brain function can be helpful for therapy of neurodegenerative
diseases. The brain consists of various types of neuron sets, which organize in three …

Optogenetics and its application in neural degeneration and regeneration

JD Ordaz, W Wu, XM Xu - Neural regeneration research, 2017 - journals.lww.com
Neural degeneration and regeneration are important topics in neurological diseases. There
are limited options for therapeutic interventions in neurological diseases that provide …

[HTML][HTML] Challenges for therapeutic applications of opsin-based optogenetic tools in humans

Y Shen, RE Campbell, DC Côté… - Frontiers in neural circuits, 2020 - frontiersin.org
As the technological hurdles are overcome and optogenetic techniques advance to have
more control over neurons, therapies based on these approaches will begin to emerge in …

The development and application of optogenetics

L Fenno, O Yizhar, K Deisseroth - Annual review of …, 2011 - annualreviews.org
Genetically encoded, single-component optogenetic tools have made a significant impact on
neuroscience, enabling specific modulation of selected cells within complex neural tissues …

Optogenetic approaches in neuroscience

A Fiala, A Suska, OM Schlüter - Current Biology, 2010 - cell.com
The recently introduced term 'optogenetics' describes a variety of techniques for expressing
genes in nerve cells that render them responsive to light. This approach makes use of light …

From optogenetic technologies to neuromodulation therapies

JC Williams, T Denison - Science translational medicine, 2013 - science.org
The field of optogenetics has provided new insight into neuronal communication and
complex brain function. Now, scientists eagerly anticipate clinical application of this …