FTY720 is a unique immunosuppressive agent that exerts its activity by inducing apoptosis
in lymphocytes. We conducted the present study to investigate the effects of FTY720 on …

Background FTY720 is a unique immunosuppressant that induces apoptosis in activated
lymphocytes, but not in other hematopoietic cells. We conducted the present study to …

Background: A unique immunosuppressant, FTY720, selectively induces apoptosis in
activated lymphocytes, but not in other hematopoietic cells. The potential that this unique …

A novel immunosuppressant FTY720 caused a significant decrease in peripheral T
lymphocytes, but not in B lymphocytes upon oral administration. This decrease was mainly a …

Aims: FTY720 is a unique immunosuppressant that induces apoptosis in activated
lymphocytes, reduces numbers of lymphocytes in peripheral blood, and prevents infiltration …

FTY720, a synthetic compound produced by modification of a metabolite from Isaria
sinclairii, is known as a unique immunosuppressive agent that exerts its activity by inducing …

The immunosuppressant FTY720 induces a drastic decrease in blood lymphocytes,
especially T cells; a decrease which is assumed to be the immunosuppressive mechanism …

Accelerated lymphocyte homing and apoptosis have been suggested to contribute to potent
immunosuppressive effects of FTY720, however, its main mechanism of action remains to be …

FTY720, a metabolite from Isaria sinclairii, has been developed to be a potent
immunosuppressive drug with induction of apoptosis in T cells and several cell lines. We …

We previously reported that FTY720 is an efficient inducer of apoptosis in lymphocytes and
cultured cell lines. In the present study, HL‐60 human promyerocytoma cells also induced …