Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis
LK Peterson, RS Fujinami - Journal of neuroimmunology, 2007 - Elsevier
Although axonal loss has been observed in demyelinated multiple sclerosis (MS) lesions,
there has been a major focus on understanding mechanisms of demyelination. However …
there has been a major focus on understanding mechanisms of demyelination. However …
Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis
MA Friese, B Schattling, L Fugger - Nature Reviews Neurology, 2014 - nature.com
Multiple sclerosis (MS) is the most frequent chronic inflammatory disease of the CNS, and
imposes major burdens on young lives. Great progress has been made in understanding …
imposes major burdens on young lives. Great progress has been made in understanding …
Pathology of multiple sclerosis and related inflammatory demyelinating diseases
A Kutzelnigg, H Lassmann - Handbook of clinical neurology, 2014 - Elsevier
This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …
including recent insights into its molecular neuropathology and immunology. It shows that all …
Cytokines and immunity in multiple sclerosis: the dual signal hypothesis
Multiple sclerosis (MS) is considered an immune-mediated disease of the central nervous
system (CNS) sustained by a chronic inflammatory process leading to patchy demyelination …
system (CNS) sustained by a chronic inflammatory process leading to patchy demyelination …
The immune response in multiple sclerosis
S Rodríguez Murúa, MF Farez… - Annual Review of …, 2022 - annualreviews.org
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …
disease that affects the central nervous system (CNS). MS is characterized by immune …
Toward identifying key mechanisms of progression in multiple sclerosis
L Husseini, A Geladaris, MS Weber - Trends in Neurosciences, 2024 - cell.com
A major therapeutic goal in the treatment of multiple sclerosis (MS) is to prevent the
accumulation of disability over an often decades-long disease course. Disability progression …
accumulation of disability over an often decades-long disease course. Disability progression …
Connecting neuroinflammation and neurodegeneration in multiple sclerosis: are oligodendrocyte precursor cells a nexus of disease?
MW Psenicka, BC Smith, RA Tinkey… - Frontiers in cellular …, 2021 - frontiersin.org
The pathology in neurodegenerative diseases is often accompanied by inflammation. It is
well-known that many cells within the central nervous system (CNS) also contribute to …
well-known that many cells within the central nervous system (CNS) also contribute to …
Neuroprotection and repair in multiple sclerosis
Multiple sclerosis (MS) is an inflammatory demyelinating disease that is considered by many
people to have an autoimmune aetiology. In recent years, new data emerging from …
people to have an autoimmune aetiology. In recent years, new data emerging from …
A basic overview of multiple sclerosis immunopathology
N Grigoriadis, V Van Pesch - European journal of neurology, 2015 - Wiley Online Library
Multiple sclerosis (MS) is a multi‐component disease characterized by inflammation,
neurodegeneration and failure of central nervous system (CNS) repair mechanisms …
neurodegeneration and failure of central nervous system (CNS) repair mechanisms …
The relevance of animal models in multiple sclerosis research
Multiple Sclerosis (MS) is a complex disease with an unknown etiology and no effective
cure, despite decades of extensive research that led to the development of several partially …
cure, despite decades of extensive research that led to the development of several partially …