Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis

LK Peterson, RS Fujinami - Journal of neuroimmunology, 2007 - Elsevier
Although axonal loss has been observed in demyelinated multiple sclerosis (MS) lesions,
there has been a major focus on understanding mechanisms of demyelination. However …

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

MA Friese, B Schattling, L Fugger - Nature Reviews Neurology, 2014 - nature.com
Multiple sclerosis (MS) is the most frequent chronic inflammatory disease of the CNS, and
imposes major burdens on young lives. Great progress has been made in understanding …

Pathology of multiple sclerosis and related inflammatory demyelinating diseases

A Kutzelnigg, H Lassmann - Handbook of clinical neurology, 2014 - Elsevier
This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

Cytokines and immunity in multiple sclerosis: the dual signal hypothesis

G Martino, R Furlan, E Brambilla, A Bergami… - Journal of …, 2000 - Elsevier
Multiple sclerosis (MS) is considered an immune-mediated disease of the central nervous
system (CNS) sustained by a chronic inflammatory process leading to patchy demyelination …

The immune response in multiple sclerosis

S Rodríguez Murúa, MF Farez… - Annual Review of …, 2022 - annualreviews.org
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …

Toward identifying key mechanisms of progression in multiple sclerosis

L Husseini, A Geladaris, MS Weber - Trends in Neurosciences, 2024 - cell.com
A major therapeutic goal in the treatment of multiple sclerosis (MS) is to prevent the
accumulation of disability over an often decades-long disease course. Disability progression …

Connecting neuroinflammation and neurodegeneration in multiple sclerosis: are oligodendrocyte precursor cells a nexus of disease?

MW Psenicka, BC Smith, RA Tinkey… - Frontiers in cellular …, 2021 - frontiersin.org
The pathology in neurodegenerative diseases is often accompanied by inflammation. It is
well-known that many cells within the central nervous system (CNS) also contribute to …

Neuroprotection and repair in multiple sclerosis

RJM Franklin, C Ffrench-Constant, JM Edgar… - Nature Reviews …, 2012 - nature.com
Multiple sclerosis (MS) is an inflammatory demyelinating disease that is considered by many
people to have an autoimmune aetiology. In recent years, new data emerging from …

A basic overview of multiple sclerosis immunopathology

N Grigoriadis, V Van Pesch - European journal of neurology, 2015 - Wiley Online Library
Multiple sclerosis (MS) is a multi‐component disease characterized by inflammation,
neurodegeneration and failure of central nervous system (CNS) repair mechanisms …

The relevance of animal models in multiple sclerosis research

A Denic, AJ Johnson, AJ Bieber, AE Warrington… - Pathophysiology, 2011 - Elsevier
Multiple Sclerosis (MS) is a complex disease with an unknown etiology and no effective
cure, despite decades of extensive research that led to the development of several partially …