Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

CS Constantinescu, N Farooqi… - British journal of …, 2011 - Wiley Online Library
Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

Neurodegeneration in autoimmune CNS inflammation

J Herz, F Zipp, V Siffrin - Experimental neurology, 2010 - Elsevier
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system, in which the myelin sheath has been considered to be the primary target for …

Neuroinflammation, neurodegeneration and regeneration in multiple sclerosis: intercorrelated manifestations of the immune response

T Koudriavtseva, C Mainero - Neural regeneration research, 2016 - journals.lww.com
Multiple sclerosis (MS) is a chronic immune-mediated inflammatory-demyelinating disorder
of the central nervous system, with a strong neurodegenerative component. The question …

Pathology of multiple sclerosis

M Kipp, P van der Valk, S Amor - CNS & Neurological …, 2012 - ingentaconnect.com
Pathological examination of the affected human tissue is key to understanding the possible
mechanisms operating in the disease. In multiple sclerosis (MS), studies of central nervous …

Cellular immunology of relapsing multiple sclerosis: interactions, checks, and balances

A Bar-Or, R Li - The Lancet Neurology, 2021 - thelancet.com
Novel insights from basic and translational studies are reshaping concepts of the
immunopathogenesis of multiple sclerosis and understanding of the different inflammatory …

What drives disease in multiple sclerosis: inflammation or neurodegeneration?

H Lassmann - Clinical and Experimental Neuroimmunology, 2010 - Wiley Online Library
Multiple sclerosis (MS) is defined as a chronic inflammatory disease of the central nervous
system, which leads to focal inflammatory demyelinated lesions with secondary …

Updates and advances in multiple sclerosis neurotherapeutics

M Amin, CM Hersh - Neurodegenerative disease management, 2023 - Taylor & Francis
The multiple sclerosis (MS) neurotherapeutic landscape is rapidly evolving. New disease-
modifying therapies (DMTs) with improved efficacy and safety, in addition to an expanding …

Promoting remyelination in multiple sclerosis: current drugs and future prospects

D Kremer, P Küry, R Dutta - Multiple Sclerosis Journal, 2015 - journals.sagepub.com
Myelin destruction due to inflammatory oligodendrocyte cell damage or death in conjunction
with axonal degeneration are among the major histopathological hallmarks of multiple …

Central nervous system remyelination: roles of glia and innate immune cells

CS Baaklini, KS Rawji, GJ Duncan, MFS Ho… - Frontiers in Molecular …, 2019 - frontiersin.org
In diseases such as multiple sclerosis (MS), inflammation can injure the myelin sheath that
surrounds axons, a process known as demyelination. The spontaneous regeneration of …

Cell type-specific intralocus interactions reveal oligodendrocyte mechanisms in MS

DC Factor, AM Barbeau, KC Allan, LR Hu… - Cell, 2020 - cell.com
Multiple sclerosis (MS) is an autoimmune disease characterized by attack on
oligodendrocytes within the central nervous system (CNS). Despite widespread use of …