Background Less than half of patients with major depressive disorder (MDD) respond to
their first antidepressant trial. Our understanding of the underlying mechanisms of selective …

The possible dose-dependency for the antidepressant effect of selective serotonin reuptake
inhibitors (SSRIs) remains controversial. We believe we have conducted the first …

Background: Selective serotonin reuptake inhibitors (SSRIs) show antidepressant properties
in many patients with a diagnosis of depression. An understanding of the underlying …

Background: Only two thirds of patients with major depression (MD) respond to
antidepressants. Thus, far applicable predictors of responsiveness to selective serotonergic …

Background: This study was conducted to determine if patients with major depressive
disorder who had previously failed treatment with one serotonin selective reuptake inhibitor …

Context Selective serotonin reuptake inhibitors (SSRIs) are often described as having a
delayed onset of effect in the treatment of depression. However, some trials have reported …

Background We previously reported higher serotonin 1A receptor (5-HT1A) binding in
subjects with major depressive disorder (MDD) during a major depressive episode using …

Selective serotonin reuptake inhibitors (SSRIs) are the first-line drugs in the treatment of
depression. Investigations of the effects of SSRIs in healthy individuals is a useful model to …

The recent questioning of the antidepressant effect of selective serotonin reuptake inhibitors
(SSRIs) is partly based on the observation that approximately half of company-sponsored …

Objective: Previous studies suggested that the treatment response to selective serotonin
reuptake inhibitors (SSRIs) in major depressive disorder follows a flat response curve within …