Plasma serotonin levels are associated with antidepressant response to SSRIs
A Holck, OM Wolkowitz, SH Mellon, VI Reus… - Journal of Affective …, 2019 - Elsevier
Background Less than half of patients with major depressive disorder (MDD) respond to
their first antidepressant trial. Our understanding of the underlying mechanisms of selective …
their first antidepressant trial. Our understanding of the underlying mechanisms of selective …
A mega-analysis of fixed-dose trials reveals dose-dependency and a rapid onset of action for the antidepressant effect of three selective serotonin reuptake inhibitors
F Hieronymus, S Nilsson, E Eriksson - Translational psychiatry, 2016 - nature.com
The possible dose-dependency for the antidepressant effect of selective serotonin reuptake
inhibitors (SSRIs) remains controversial. We believe we have conducted the first …
inhibitors (SSRIs) remains controversial. We believe we have conducted the first …
The effect of selective serotonin reuptake inhibitors in healthy subjects. A systematic review
U Knorr, LV Kessing - Nordic journal of psychiatry, 2010 - Taylor & Francis
Background: Selective serotonin reuptake inhibitors (SSRIs) show antidepressant properties
in many patients with a diagnosis of depression. An understanding of the underlying …
in many patients with a diagnosis of depression. An understanding of the underlying …
Neuropsychological functioning in major depression and responsiveness to selective serotonin reuptake inhibitors antidepressants
O Kampf-Sherf, Z Zlotogorski, A Gilboa… - Journal of affective …, 2004 - Elsevier
Background: Only two thirds of patients with major depression (MD) respond to
antidepressants. Thus, far applicable predictors of responsiveness to selective serotonergic …
antidepressants. Thus, far applicable predictors of responsiveness to selective serotonergic …
Fluoxetine treatment of patients with major depressive disorder who failed initial treatment with sertraline
ME Thase, SL Blomgren, MA Birkett… - Journal of Clinical …, 1997 - psychiatrist.com
Background: This study was conducted to determine if patients with major depressive
disorder who had previously failed treatment with one serotonin selective reuptake inhibitor …
disorder who had previously failed treatment with one serotonin selective reuptake inhibitor …
Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis
MJ Taylor, N Freemantle, JR Geddes… - Archives of general …, 2006 - jamanetwork.com
Context Selective serotonin reuptake inhibitors (SSRIs) are often described as having a
delayed onset of effect in the treatment of depression. However, some trials have reported …
delayed onset of effect in the treatment of depression. However, some trials have reported …
Brain serotonin 1A receptor binding as a predictor of treatment outcome in major depressive disorder
Background We previously reported higher serotonin 1A receptor (5-HT1A) binding in
subjects with major depressive disorder (MDD) during a major depressive episode using …
subjects with major depressive disorder (MDD) during a major depressive episode using …
The effect of selective serotonin reuptake inhibitors in healthy subjects revisited: A systematic review of the literature.
Selective serotonin reuptake inhibitors (SSRIs) are the first-line drugs in the treatment of
depression. Investigations of the effects of SSRIs in healthy individuals is a useful model to …
depression. Investigations of the effects of SSRIs in healthy individuals is a useful model to …
Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression
F Hieronymus, JF Emilsson, S Nilsson… - Molecular psychiatry, 2016 - nature.com
The recent questioning of the antidepressant effect of selective serotonin reuptake inhibitors
(SSRIs) is partly based on the observation that approximately half of company-sponsored …
(SSRIs) is partly based on the observation that approximately half of company-sponsored …
Systematic review and meta-analysis: dose-response relationship of selective serotonin reuptake inhibitors in major depressive disorder
E Jakubovski, AL Varigonda… - American Journal of …, 2016 - Am Psychiatric Assoc
Objective: Previous studies suggested that the treatment response to selective serotonin
reuptake inhibitors (SSRIs) in major depressive disorder follows a flat response curve within …
reuptake inhibitors (SSRIs) in major depressive disorder follows a flat response curve within …