ABSTRACT B7-H4, an immune suppressive member of the B7 family, is highly expressed in
a wide variety of human malignancies making it an attractive immunotherapeutic target …

Abstract Background B7-H3 and B7-H4 are highly expressed by many human malignancies
making them attractive immunotherapeutic targets. However, their expression patterns and …

Abstract B7-H4, a tumor-associated cell surface protein, is expressed in endometrioid (EM),
serous (SE), and clear cell (CC) ovarian carcinomas. Prior in vitro studies from other groups …

Abstract B7-H3 and B7x are members of the B7 family of immune regulatory ligands that are
thought to attenuate peripheral immune responses through co-inhibition. Previous studies …

B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells
resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation …

Tumor-associated macrophages are a prominent component of ovarian cancer stroma and
contribute to tumor progression. B7-H4 is a recently identified B7 family molecule. We show …

B7-H4 is a recently identified B7 family member. We previously showed that ovarian tumor
and associated macrophages expressed B7-H4; tumor B7-H4+ macrophages and CD4+ …

Background B7-H7 is a newly identified member of the B7 immune checkpoint family, but
has not been investigated in epithelial ovarian cancer (EOC). This study aimed to determine …

Abstract Although PD-L1/PD-1 blockade therapy has been approved to treat many types of
cancers, the majority of patients with solid tumors do not respond well, but the underlying …

A number of members of the B7 superfamily of ligands have been implicated in tumor
immunogenicity and cancer development. Two of these recently characterized ligands, B7 …