Glipizide is a class-II antidiabetic drug which is purely insoluble in water. Since only
dissolved drug can pass the gastro intestinal membrane, proper solubility of the drug is …

The poor solubility of drug substances in water and their low dissolution rate in aqueous GIT
fluid often leads toinsufficient bioavailability. Glipizide is a class-II antidiabetic drug which is …

The aim of this study was to increase the solubility and dissolution of Glipizide in water by
solid dispersion. The solid dispersion of glipizide was prepared using water soluble carriers …

Enhancement of solubility and dissolution of glipizide by solid dispersion (kneading)
technique Page 1 245 Asian Journal of Pharmaceutics - July-September 2009 …

The solubility behavior of drugs remains one of the most challenging aspects in formulation
development. Most NCE are poorly water soluble drugs, not well-absorbed after oral …

Glipizide is an oral blood glucose lowering drug of the sulfonylurea class. It is characterized
by its poor aqueous solubility. To overcome this problem in addition to improve the …

Pioglitazone hydrochloride is a novel antidiabetic drug in thiazolidinediones group and it
improves insulin sensitivity in insulin resistant patients. One of the major problems with this …

The present work investigates the dissolution and bioavailability characteristics of an anti-
diabetic drug, Glimepiride. Glimepiride, is an oral hypoglycemic drug and has problems in …

Glimepiride is one of the third generation sulfonylurea used for treatment of type 2 diabetes.
Poor aqueous solubility and slow dissolution rate of the glimepiride lead to irreproducible …

Glipizide (GZ) is an oral blood-glucose-lowering drug of the sulfonylurea class characterized
by its poor aqueous solubility. Aiming for the production of GZ tablets with rapid onset of …