How the genetics of lung cancer may overlap with COPD

RP Young, RJ Hopkins - Respirology, 2011 - Wiley Online Library
Over the last 30 years, epidemiological studies have shown that COPD is the single most
important risk factor for lung cancer after smoking exposure. Recent genetic studies using …

Genetic evidence linking lung cancer and COPD: a new perspective

RP Young, RJ Hopkins, GD Gamble… - The application of …, 2011 - Taylor & Francis
Epidemiological studies indicate that tobacco smoke exposure accounts for nearly 90% of
cases of chronic obstructive pulmonary disease (COPD) and lung cancer. However, genetic …

Genetic predisposition to chronic obstructive pulmonary disease and/or lung cancer: important considerations when evaluating risk

RA El-Zein, RP Young, RJ Hopkins, CJ Etzel - Cancer prevention research, 2012 - AACR
Chronic obstructive pulmonary disease (COPD) is defined as a disease causing an airflow
limitation that is not fully reversible. COPD is phenotypically complex and characterized by …

Lung cancer and chronic obstructive pulmonary disease: needs and opportunities for integrated research

A Punturieri, E Szabo, TL Croxton… - Journal of the …, 2009 - academic.oup.com
Lung cancer and chronic obstructive pulmonary disease (COPD) are leading causes of
morbidity and mortality in the United States and worldwide. They share a common …

Common pathogenic mechanisms and pathways in the development of COPD and lung cancer

IA Yang, V Relan, CM Wright… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Lung cancer and COPD commonly coexist in smokers, and the presence of
COPD increases the risk of developing lung cancer. In addition to smoking cessation and …

Mechanistic links between COPD and lung cancer

AMG Houghton - Nature Reviews Cancer, 2013 - nature.com
Numerous epidemiological studies have consistently linked the presence of chronic
obstructive pulmonary disease (COPD) to the development of lung cancer, independently of …

[HTML][HTML] Chronic obstructive pulmonary disease as a risk factor for lung cancer

Y Takiguchi, I Sekine, S Iwasawa… - World journal of …, 2014 - ncbi.nlm.nih.gov
The association between chronic obstructive pulmonary disease (COPD) and lung cancer
has long been a subject of intense debate. The high prevalence of COPD in elderly smokers …

Mechanisms involved in lung cancer development in COPD

G Caramori, P Casolari, GN Cavallesco… - The international journal …, 2011 - Elsevier
Lung cancer and chronic obstructive pulmonary disease (COPD) are leading causes of
morbidity and mortality worldwide. They share a common environmental risk factor in …

Mechanisms contributing to the comorbidity of COPD and lung cancer

A Forder, R Zhuang, VGP Souza, LJ Brockley… - International Journal of …, 2023 - mdpi.com
Lung cancer and chronic obstructive pulmonary disease (COPD) often co-occur, and
individuals with COPD are at a higher risk of developing lung cancer. While the underlying …

Familial lung cancer: genetic susceptibility and relationship to chronic obstructive pulmonary disease

AG Schwartz, JC Ruckdeschel - American journal of respiratory and …, 2006 - atsjournals.org
Lung cancer continues to be the leading cause of cancer death, and although most lung
cancer is attributable to cigarette smoking, underlying genetic susceptibility is suggested by …