Mosaicism is the presence of cells within an organism that have a different genetic
composition despite deriving from a single zygote. The consequence of this depends on the …

Somatic genome variations (mosaicism) seem to represent a common mechanism for
human intercellular/interindividual diversity in health and disease. However, origins and …

Low-level somatic chromosomal mosaicism, which usually arises from post-zygotic errors, is
a known cause of several well defined genetic syndromes and has been implicated in …

Human disease is rarely a matter of all or nothing; variable expressivity is generally
observed. Part of this variability is explained by somatic mosaicism, which can arise by a …

Genomic technologies, including next-generation sequencing (NGS) and single-nucleotide
polymorphism (SNP) microarrays, have provided unprecedented opportunities to assess …

Mosaic chromosomal alterations (mCAs) are frequently observed in cancer cells and are
regarded as one of the common features of cancers. Strikingly, accumulating studies …

Nearly every mammalian cell division is accompanied by a mutational event that becomes
fixed in a daughter cell. When carried forward to additional cell progeny, a clone of variant …

Contrary to earlier beliefs, every cell in the individual is genetically different due to somatic
mutations. Consequently, tissues become a mixture of cells with distinct genomes, a …

Identifying genetic mosaicism is important in establishing a diagnosis, assessing recurrence
risk, and providing accurate genetic counseling. Next-generation sequencing has allowed …

Mosaicism—the existence of genetically distinct populations of cells in a particular organism—
is an important cause of genetic disease. Mosaicism can appear as de novo DNA mutations …