Polyamines (putrescine, spermidine, and spermine) play an essential role in cell growth,
differentiation, and apoptosis. Protein kinase C (PKC) stimulates polyamine biosynthesis …

Ornithine decarboxylase (ODC) is the first rate-limiting enzyme in polyamine biosynthesis,
which is essential for cell survival. We hypothesized that the ODC/polyamine system is …

Background. Ischemic preconditioning (IPC) strongly protects against myocardial ischemia
reperfusion (IR) injury. However, IPC protection is ineffective in aged hearts. Exercise …

Polyamines play a role in ischemia-reperfusion injury of brain, kidney and probably heart.
Primary data on cardiac myoblasts suggested that the induction of polyamine metabolism …

Apoptotic cell death of cardiomyocytes is involved in several cardiovascular diseases
including ischemia, hypertrophy, and heart failure. The polyamines putrescine, spermidine …

Two lines of transgenic mice were produced with constitutive expression of antizyme-1 in the
heart, driven from the cardiac α-myosin heavy chain promoter. The use of engineered …

Abstract We incubated neonatal Sprague—Dawley rat cardiomyocytes in primary culture in
a medium simulating ischemia (consisting of hypoxia plus serum deprivation) for 2 h, then re …

The role that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in
polyamine biosynthesis, by beta‐adrenergic agents may have in heart hypertrophy is a …

Objective: Ornithine decarboxylase (ODC) is an initial rate-limiting enzyme in the synthesis
of polyamines (putrescine, spermidine, and spermine) that play a role in cell growth and …

Myocardial infarction (MI) is associated with a high mortality rate, which is attributed to the
effects of myocyte loss that occurs as a result of ischemia-induced cell death. Very few …