Purpose The goal of this study was to investigate the ability of saquinavir to generate the in
vivo supersaturation and the impact of the presence of another solute, ie, ritonavir, on the …

Supersaturated drug delivery systems are generally developed for improving solubility and
dissolution of poorly soluble drugs. Supersaturation is a high energy state with a tendency to …

Introduction: With the increasing number of poorly water-soluble compounds in drug
discovery pipelines, supersaturating drug delivery systems (SDDS) have attracted increased …

In order to investigate the supersaturation propensity of drugs in a simple and small-scale
setup, induction of supersaturation is often performed via solvent shift. For weak bases, a …

Precipitation testing, especially for weakly basic APIs, represents a key parameter in drug
substance characterization during early development stages, where the amount of API …

In order to better understand the oral absorption behavior of poorly water-soluble drugs,
their supersaturation–nucleation behavior was characterized in fasted state simulated …

At present, the majority of APIs synthesized today remain challenging tasks for formulation
development. Many technologies are being utilized or explored for enhancing solubility …

Assessing the effect of the molecular weight of excipients like Hydroxypropyl methyl
cellulose (HPMC) and Polyvinylpyrrolidone (PVP) on their ability to attain and maintain the …

A variety of enabling formulations has been developed to address poor oral drug absorption
caused by insufficient dissolution in the gastrointestinal tract. As the in vivo performance of …

Purpose Delaying precipitation of weakly basic drugs in supersaturated state following their
transition from the acidic gastric environment to the near-neutral proximal small intestinal …