Relationship of ion channel activity to control of myometrial calcium

BM Sanborn - The Journal of the Society for Gynecologic …, 2000 - Springer
This article reviews the contribution of ion channels to membrane potential, the ion channels
expressed in myometrium, and the effect of ion channel activity on the control of myometrial …

Ion channels and the control of myometrial electrical activity

BM Sanborn - Seminars in perinatology, 1995 - Elsevier
A rise in intracellular calcium (Ca 2+) is central to control of contractile activity in myometrium
(see first and second articles in this issue). In nervous tissue, sodium (Na § entry into tissue …

Calcium signaling and uterine contractility

S Wrayzx, K Jones, S Kupittayanant… - Journal of the …, 2003 - journals.sagepub.com
Changes in Ca2+ signals within the myometrium have important functional consequences,
as they determine contractility. We show that the basic phasic nature of uterine contractions …

Control of Uterine Ca2+ by Membrane Voltage: Toward Understanding the Excitation–Contraction Coupling in Human Myometrium

A Shmygol, AM Blanks… - Annals of the New …, 2007 - Wiley Online Library
Myometrial contractility is a complex and dynamic physiological process that changes
substantially during pregnancy and culminates in childbirth. Uterine contractions are …

Calcium-activated K+ channels as modulators of human myometrial contractile activity

K Anwer, C Oberti, GJ Perez… - … of Physiology-Cell …, 1993 - journals.physiology.org
The role of Ca (2+)-activated potassium (KCa) channels in the regulation of membrane
potential, intracellular free calcium ([Ca2+] i) and contraction was investigated in uterine …

Electrophysiological characterization and functional importance of calcium-activated chloride channel in rat uterine myocytes

K Jones, A Shmygol, S Kupittayanant, S Wray - Pflügers Archiv, 2004 - Springer
In order to better understand the mechanisms underlying excitation of the uterus, we have
elucidated the characteristics and functional importance of Ca 2+-activated Cl− currents (I Cl …

Potassium channels in the human myometrium

RN Khan, B Matharoo-Ball, S Arulkumaran… - Experimental …, 2001 - cambridge.org
The contractility of the human uterus is under the fine control of a variety of interacting
bioactive agents. During labour, the excitability of the uterus is drastically transformed in …

Differential modulation of large-conductance KCa channels by PKA in pregnant and nonpregnant myometrium

G Perez, L Toro - American Journal of Physiology-Cell …, 1994 - journals.physiology.org
Uterine excitability depends on ion channel activity, the expression of which is regulated by
sexual hormones. We show now that the action of protein kinase A (PKA) on large …

Direct measurement of intracellular free calcium in cultured human puerperal myometrial cells stimulated by oxytocin: effects of extracellular calcium and calcium …

K TASAKA, N MASUMOTO, A MIYAKE… - Obstetrics & …, 1991 - journals.lww.com
The changes in intracellular free calcium concentration [Ca 2+] i) induced by oxytocin in
single cells of cultured human puerperal myometrium were measured with the calcium …

Contribution of calcium-sensitive potassium channels to NS1619-induced relaxation in human pregnant myometrium.

RN Khan, SK Smith, ML Ashford - Human reproduction (Oxford …, 1998 - academic.oup.com
Large-conductance, calcium-sensitive potassium channels (BK (Ca)) are found at high
density in the pregnant human myometrium. We have investigated, using isolated …