Many human Y-chromosomal deletions are thought to severely impair reproductive fitness,
which precludes their transmission to the next generation and thus ensures their rarity in the …

The Y chromosome provides a unique opportunity to study mutational processes within the
human genome, decoupled from the confounding effects of interchromosomal …

The prevalence of highly repetitive sequences within the human Y chromosome has
prevented its complete assembly to date and led to its systematic omission from genomic …

Once considered to be a genetic wasteland of no scientific interest beyond sex
determination, the human Y chromosome has made a significant comeback in the past few …

Although much structural polymorphism in the human genome has been catalogued,,,,, the
kinetics of underlying change remain largely unexplored. Because human Y chromosomes …

We have detected deletions of portions of the Y chromosome long arm in 12 of 89 men with
azoospermia (no sperm in semen). No Y deletions were detected in their male relatives or in …

The human Y chromosome is replete with amplicons—very large, nearly identical repeats—
which render it susceptible to interstitial deletions that often cause spermatogenic failure …

The human Y chromosome shows frequent structural variants, some of which are selectively
neutral, while others cause impaired fertility due to the loss of spermatogenic genes. The …

Deletions of the AZFc (azoospermia factor c) region of the Y chromosome are the most
common known cause of spermatogenic failure. We determined the complete nucleotide …

Purpose The human Y chromosome plays a central role in sex determination and
spermatogenesis. The azoospermia factor (AZF) loci on the Y chromosome contain genes …