The study of somatic mutations and the associated clonal mosaicism across the human body
has transformed our understanding of aging and its links to cancer. In proliferative human …

Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …

The age-related expansion of hematopoietic stem cell clones carrying somatic mutations is
known as clonal hematopoiesis and is linked to hematologic malignancies, cardiovascular …

Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Aging is characterized by increased mortality, functional decline, and exponential increases
in the incidence of diseases such as cancer, stroke, cardiovascular disease, neurological …

Somatic mutations are an unavoidable consequence of aging tissues. Even though most
mutations are functionally silent, some may affect genes critical to proper tissue self-renewal …

Over the course of the human life span, somatic DNA mutations accumulate in healthy
tissues. This process has been most clearly described in blood and bone marrow …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

The recent characterization of clonal hematopoiesis in a large segment of the aging
population has raised tremendous interest and concern alike. Mutations have been …

Clonal hematopoiesis (CH) represents the clonal expansion of hematopoietic stem cells and
their progeny driven by somatic mutations. Accurate risk assessment of CH is critical for …