Although the diagnostic criteria of in-situ and invasive adenocarcinomas of the cervix uteri
are well established, the differentiation from benign mimics may be difficult and the …

As only a minority of low-grade dysplastic lesions of the cervix uteri will eventually progress
to carcinoma, predicting the behavior of these lesions could be of high value in clinical …

Early detection of premalignant and malignant glandular lesions of the uterine cervix and
their distinction from benign mimics is crucial but sometimes difficult. In this study, we …

Abstract p16 INK4a is a tumor suppressor gene that plays a central role in the regulation of
the cell cycle. In squamous cervical cancers, overexpression of p16 INK4a is induced by …

Objectives Cervical adenocarcinoma has been increasing in frequency, particularly among
young women. Its diagnosis still presents many challenges. In addition to the difficulty in …

The morphologic diagnosis of squamous and glandular dysplasia in cervical biopsies may
be complicated by a variety of inflammatory and hormonal conditions. Cellular changes …

Human papillomavirus (HPV) is recognized as a causal agent for cervical carcinomas.
Assimilation of HPV oncogenes E6 and E7 into the host DNA promotes upregulation of …

The immunohistochemical expression of p16 INK4a in formalin-fixed and paraffin-
embedded histological sections was evaluated in a retrospective study comprising a low …

The aim of the study was to evaluate the immunohistochemical expression of p16 INK4a as
a marker of progression risk in low-grade dysplastic lesions of the cervix uteri. p16 INK4a …

Abstract p16 is a cyclin-dependent kinase-4 inhibitor that is expressed in a limited range of
normal tissues and tumors. In recent years, immunohistochemistry with p16 antibodies has …