Mosaic chromosomal alterations (mCAs) are structural alterations associated with aging,
cancer, cardiovascular disease, infectious diseases, and mortality. The distribution of mCAs …

One of the most curious findings emerged from genome-wide studies over the last decade
was that genetic mosaicism is a dominant feature of human ageing genomes. The clonal …

Mosaic chromosomal alterations (mCAs) are frequently observed in cancer cells and are
regarded as one of the common features of cancers. Strikingly, accumulating studies …

Mosaic chromosomal alterations (mCAs) are the clonal expansion of large somatically
acquired structural chromosomal changes present on the autosomes and sex …

Men have a shorter life expectancy compared with women but the underlying factor (s) are
not clear. Late-onset, sporadic Alzheimer disease (AD) is a common and lethal …

Genetic mutations accumulate in an organism's body throughout its lifetime. While somatic
single-nucleotide variants have been well characterized in the human body, the patterns …

Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to
infectious disease risk are incompletely understood. Age-related mosaic chromosomal …

Background: Cancer survivors are at an increased risk of cardiovascular disease (CVD)
compared with the general population. We sought to evaluate the impact of mosaic …

Human genetic mosaicism is the presence of two or more cellular populations with distinct
genotypes in an individual who developed from a single fertilized ovum. While initially …

Clonal mosaicism arises when a postzygotic mutational event is detectable in
subpopulations of cells as an alternative genotype while not present in the germline …