Long noncoding RNA in cancer: wiring signaling circuitry
C Lin, L Yang - Trends in cell biology, 2018 - cell.com
Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the
human genome, may hold missing drivers of cancer and have gained attention recently as a …
human genome, may hold missing drivers of cancer and have gained attention recently as a …
[HTML][HTML] Long noncoding RNAs in cancer: mechanisms of action and technological advancements
The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to
being defined as a category of genetic elements, leaving its mark on the field of cancer …
being defined as a category of genetic elements, leaving its mark on the field of cancer …
Small and long non-coding RNAs: novel targets in perspective cancer therapy
C Han Li, Y Chen - Current genomics, 2015 - ingentaconnect.com
Non-coding RNA refers to a large group of endogenous RNA molecules that have no protein
coding capacity, while having specialized cellular and molecular functions. They possess …
coding capacity, while having specialized cellular and molecular functions. They possess …
Noncoding RNA as an influential epigenetic modulator with promising roles in cancer therapeutics
L Roy, O Chatterjee, D Bose, A Roy, S Chatterjee - Drug Discovery Today, 2023 - Elsevier
The epigenetic landscape has an important role in cellular homeostasis and its deregulation
leads to cancer. Noncoding (nc) RNA networks function as major regulators of cellular …
leads to cancer. Noncoding (nc) RNA networks function as major regulators of cellular …
Long noncoding RNAs in cancer: from function to translation
While our understanding of the molecular mechanisms underlying cancer has significantly
improved, most of our knowledge focuses on protein-coding genes that make up a fraction of …
improved, most of our knowledge focuses on protein-coding genes that make up a fraction of …
[HTML][HTML] Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer
L Nie, HJ Wu, JM Hsu, SS Chang… - American journal of …, 2012 - ncbi.nlm.nih.gov
With rapid development of sequencing technologies such as deep sequencing and whole
genome high-density tiling array, we now know that most of the “junk” genomic sequences …
genome high-density tiling array, we now know that most of the “junk” genomic sequences …
[HTML][HTML] Long non-coding RNAs in stem cells and cancer
G Eades, YS Zhang, QL Li, JX Xia, Y Yao… - World journal of clinical …, 2014 - ncbi.nlm.nih.gov
An overwhelming majority of the transcribed genome encodes for non-coding RNA (ncRNA)
sequences. Deep sequencing of the transcriptome has uncovered tens of thousands of long …
sequences. Deep sequencing of the transcriptome has uncovered tens of thousands of long …
Emerging roles of long non‐coding RNA in cancer
A Sanchez Calle, Y Kawamura, Y Yamamoto… - Cancer …, 2018 - Wiley Online Library
Since comprehensive analysis of the mammalian genome revealed that the majority of
genomic products are transcribed in long non‐coding RNA (lnc RNA), increasing attention …
genomic products are transcribed in long non‐coding RNA (lnc RNA), increasing attention …
[HTML][HTML] Noncoding RNAs in cancer therapy resistance and targeted drug development
WT Wang, C Han, YM Sun, TQ Chen… - Journal of hematology & …, 2019 - Springer
Noncoding RNAs (ncRNAs) represent a large segment of the human transcriptome and
have been shown to play important roles in cellular physiology and disease pathogenesis …
have been shown to play important roles in cellular physiology and disease pathogenesis …
Long noncoding RNAs as new architects in cancer epigenetics, prognostic biomarkers, and potential therapeutic targets
D Meseure, K Drak Alsibai, A Nicolas… - BioMed research …, 2015 - Wiley Online Library
Recent advances in genome‐wide analysis have revealed that 66% of the genome is
actively transcribed into noncoding RNAs (ncRNAs) while less than 2% of the sequences …
actively transcribed into noncoding RNAs (ncRNAs) while less than 2% of the sequences …