Vitamin E protects against alcohol-induced cell loss and oxidative stress in the neonatal rat hippocampus
MD Marino, MY Aksenov, SJ Kelly - International Journal of Developmental …, 2004 - Elsevier
Oxidative stress has been proposed as a possible mechanism underlying nervous system
deficits associated with Fetal Alcohol Syndrome (FAS). Current research suggests that …
deficits associated with Fetal Alcohol Syndrome (FAS). Current research suggests that …
Vitamin E and β-carotene protect against ethanol combined with ischemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome
JJ Mitchell, M Paiva, MB Heaton - Neuroscience letters, 1999 - Elsevier
Neurodevelopmental damage can occur as a result of in utero exposure to alcohol.
Oxidative stress processes are one of many proposed mechanisms thought to contribute to …
Oxidative stress processes are one of many proposed mechanisms thought to contribute to …
The antioxidants vitamin E and β-carotene protect against ethanol-induced neurotoxicity in embryonic rat hippocampal cultures
JJ Mitchell, M Paiva, MB Heaton - Alcohol, 1999 - Elsevier
Fetal alcohol syndrome is characterized by numerous nervous system anomalies with the
developing hippocampus being highly vulnerable. Other conditions can result from maternal …
developing hippocampus being highly vulnerable. Other conditions can result from maternal …
Amelioration of ethanol‐induced neurotoxicity in the neonatal rat central nervous system by antioxidant therapy
MB Heaton, JJ Mitchell, M Paiva - Alcoholism: Clinical and …, 2000 - Wiley Online Library
Background: The cerebellum of the neonatal rat is highly susceptible to ethanol, with
profound loss of Purkinje cells resulting from even brief exposure during the first postnatal …
profound loss of Purkinje cells resulting from even brief exposure during the first postnatal …
A review of interventions against fetal alcohol spectrum disorder targeting oxidative stress
Y Zhang, H Wang, Y Li, Y Peng - International Journal of Developmental …, 2018 - Elsevier
Introduction Fetal alcohol spectrum disorder is caused by maternal ethanol exposure; it
causes physical, behavioral, cognitive, and neural impairments (Murawski et al., 2015) …
causes physical, behavioral, cognitive, and neural impairments (Murawski et al., 2015) …
Ethanol influences on Bax translocation, mitochondrial membrane potential, and reactive oxygen species generation are modulated by vitamin E and brain‐derived …
MB Heaton, M Paiva… - Alcoholism: Clinical and …, 2011 - Wiley Online Library
Background: This study investigated ethanol influences on intracellular events that
predispose developing neurons toward apoptosis and the capacity of the antioxidant α …
predispose developing neurons toward apoptosis and the capacity of the antioxidant α …
The effects of ethanol exposure during distinct periods of brain development on oxidative stress in the adult rat brain
PS Brocardo, J Gil‐Mohapel, R Wortman… - Alcoholism: Clinical …, 2017 - Wiley Online Library
Background The consumption of alcohol during pregnancy can result in abnormal fetal
development and impaired brain function in humans and experimental animal models …
development and impaired brain function in humans and experimental animal models …
Ascorbic acid inhibits ROS production, NF-κB activation and prevents ethanol-induced growth retardation and microencephaly
Y Peng, KHH Kwok, PH Yang, SSM Ng, J Liu… - …, 2005 - Elsevier
In this study, we established an embryo model to study the effects of ethanol on fetal
development. When embryos of Xenopus laevis (the African clawed frog) were exposed to …
development. When embryos of Xenopus laevis (the African clawed frog) were exposed to …
Vitamin E amelioration of ethanol neurotoxicity involves modulation of apoptotis-related protein levels in neonatal rat cerebellar granule cells
MB Heaton, I Madorsky, M Paiva… - Developmental brain …, 2004 - Elsevier
Developmental ethanol exposure leads to a variety of abnormalities in the central nervous
system (CNS). Mechanisms proposed as underlying these effects include alterations of …
system (CNS). Mechanisms proposed as underlying these effects include alterations of …
The role of oxidative stress in fetal alcohol spectrum disorders
The ingestion of alcohol/ethanol during pregnancy can result in abnormal fetal development
in both humans and a variety of experimental animal models. Depending on the pattern of …
in both humans and a variety of experimental animal models. Depending on the pattern of …