[HTML][HTML] The role of WDR76 protein in human diseases

J Yang, F Wang, B Chen - Bosnian Journal of Basic Medical …, 2021 - ncbi.nlm.nih.gov
The WD40 repeat (WDR) domain is one of the most abundant protein interaction domains in
the human proteome. More than 360 protein interaction domains have been annotated thus …

[HTML][HTML] Phage-display based discovery and characterization of peptide ligands against WDR5

J Cao, T Fan, Y Li, Z Du, L Chen, Y Wang, X Wang… - Molecules, 2021 - mdpi.com
WD40 is a ubiquitous domain presented in at least 361 human proteins and acts as scaffold
to form protein complexes. Among them, WDR5 protein is an important mediator in several …

Systematic analysis of the oncogenic role of WDR62 in human tumors

Y Bu, L Zhang, X Ma, R Wang, X Zhang, J Li - Disease Markers, 2021 - Wiley Online Library
Background. Emerging studies support the oncogenic role of WD repeat domain 62
(WDR62) in few tumors, while no pan‐cancer analysis is available. In this study, we …

Biochemical reduction of the topology of the diverse WDR76 protein interactome

G Dayebgadoh, ME Sardiu, L Florens… - Journal of proteome …, 2019 - ACS Publications
A hub protein in protein interaction networks will typically have a large number of diverse
interactions. Determining the core interactions and the function of such a hub protein …

WDR62 overexpression is associated with a poor prognosis in patients with lung adenocarcinoma

K Shinmura, H Kato, Y Kawanishi… - Molecular …, 2017 - Wiley Online Library
Human WDR62, which is localized in the cytoplasm including the centrosome, is known to
be responsible for primary microcephaly; however, the role of WDR62 abnormality in …

Identification of WD‐Repeat Protein 72 as a Novel Prognostic Biomarker in Non‐Small‐Cell Lung Cancer

G Shi, Q Ni, Y Miao, H Huang, Z Yin… - Mediators of …, 2023 - Wiley Online Library
WD‐repeat protein 72 (WDR72; OMIM∗ 613214), a scaffolding protein lacking intrinsic
enzymatic activity, produces numerous β‐propeller blade formations, serves as a binding …

[HTML][HTML] High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis

DJ Hu, WJ Shi, M Yu, L Zhang - Oncology Letters, 2019 - spandidos-publications.com
The WD‑repeat domain (WDR) family is distributed in the majority of eukaryotes and has
several unique biological functions. It serves important roles in signal transduction …

[HTML][HTML] The correlation of WDR76 expression with survival outcomes and immune infiltrates in lung adenocarcinoma

L Fang, G Yu, W Yu, G Chen, B Ye - PeerJ, 2021 - peerj.com
Background WD repeat domain 76 (WDR76) is a predicted member of the WD40-repeat-
containing domain superfamily and possibly involves in various biological processes, but its …

[HTML][HTML] Aberrant expression of WDR4 affects the clinical significance of cancer immunity in pan-cancer

H Zeng, S Xu, E Xia, S Hirachan, A Bhandari… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Recent publications have presented research showing that WD repeat domain 4 (WDR4)
plays a significant role in various kinds of malignant tumours. However, the expression …

[HTML][HTML] Effect of high WDR5 expression on the hepatocellular carcinoma prognosis

Z Cui, H Li, F Liang, C Mu, Y Mu… - Oncology …, 2018 - spandidos-publications.com
Abstract WD repeat domain 5 (WDR5) serves an important role in various biological
functions through the epigenetic regulation of gene transcription. Aberrant expression of …