Lymph nodes that lie immediately downstream of tumors [tumor‐draining lymph nodes
(TDLNs)] undergo profound alterations due to the presence of the upstream tumor. The …

The tumor-draining lymph nodes (TDLNs) are the primary sites of the development of anti-
tumor immunity. Primary tumor irradiation promotes 'radio-vaccination'by enhancing the …

Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …

Limited representation of intratumoral immune cells is a major barrier to tumor control.
However, simply enhancing immune responses in tumor-draining lymph nodes or through …

BACKGROUND Although, to the authors' knowledge, no prospective randomized clinical
trial has demonstrated improvement in survival following the radical dissection of lymph …

Highlights•Tumours induce growth and remodelling of lymphatics which is linked with
metastasis.•Lymphatic vessels modulate antitumour immunity in tumours and draining lymph …

Triple negative breast cancer (TNBC) is a significant clinical problem to which
immunotherapeutic strategies have been applied with limited success. Using the syngeneic …

Tertiary lymphoid structures as hubs of antitumour immunity | Nature Reviews Cancer Skip to
main content Thank you for visiting nature.com. You are using a browser version with limited …

In recent years, it has become apparent that immunoregulatory processes influence cancer
development. The key players in tumor progression are mainly present in the …

In studying the histology and immunohistology of tumor-draining lymph nodes, we observed
that nodes close to tumor showed reduced paracortical activity relative to those further away …