Statistically optimal force aggregation for coarse-graining molecular dynamics

A Krämer, AEP Durumeric, NE Charron… - The Journal of …, 2023 - ACS Publications
Machine-learned coarse-grained (CG) models have the potential for simulating large
molecular complexes beyond what is possible with atomistic molecular dynamics. However …

Coarse-graining with equivariant neural networks: A path toward accurate and data-efficient models

TD Loose, PG Sahrmann, TS Qu… - The Journal of Physical …, 2023 - ACS Publications
Machine learning has recently entered into the mainstream of coarse-grained (CG)
molecular modeling and simulation. While a variety of methods for incorporating deep …

Contrastive learning of coarse-grained force fields

X Ding, B Zhang - Journal of chemical theory and computation, 2022 - ACS Publications
Coarse-grained models have proven helpful for simulating complex systems over long time
scales to provide molecular insights into various processes. Methodologies for systematic …

Two for one: Diffusion models and force fields for coarse-grained molecular dynamics

M Arts, V Garcia Satorras, CW Huang… - Journal of Chemical …, 2023 - ACS Publications
Coarse-grained (CG) molecular dynamics enables the study of biological processes at
temporal and spatial scales that would be intractable at an atomistic resolution. However …

Neural network based prediction of conformational free energies-a new route toward coarse-grained simulation models

T Lemke, C Peter - Journal of chemical theory and computation, 2017 - ACS Publications
Coarse-grained (CG) simulation models have become very popular tools to study complex
molecular systems with great computational efficiency on length and time scales that are …

A review of advancements in coarse-grained molecular dynamics simulations

SY Joshi, SA Deshmukh - Molecular Simulation, 2021 - Taylor & Francis
Over the last few years, coarse-grained molecular dynamics has emerged as a way to model
large and complex systems in an efficient and inexpensive manner due to its lowered …

[HTML][HTML] Multi-body effects in a coarse-grained protein force field

J Wang, N Charron, B Husic, S Olsson, F Noé… - The Journal of …, 2021 - pubs.aip.org
The use of coarse-grained (CG) models is a popular approach to study complex
biomolecular systems. By reducing the number of degrees of freedom, a CG model can …

Flow-matching: Efficient coarse-graining of molecular dynamics without forces

J Kohler, Y Chen, A Kramer, C Clementi… - Journal of Chemical …, 2023 - ACS Publications
Coarse-grained (CG) molecular simulations have become a standard tool to study molecular
processes on time and length scales inaccessible to all-atom simulations. Parametrizing CG …

Machine learning of coarse-grained molecular dynamics force fields

J Wang, S Olsson, C Wehmeyer, A Pérez… - ACS central …, 2019 - ACS Publications
Atomistic or ab initio molecular dynamics simulations are widely used to predict
thermodynamics and kinetics and relate them to molecular structure. A common approach to …

A review of physics-based coarse-grained potentials for the simulations of protein structure and dynamics

H Shen, Z Xia, G Li, P Ren - Annual Reports in Computational Chemistry, 2012 - Elsevier
By simplifying the atomistic representation of a biomolecular system, coarse-grained (CG)
approach enables the molecular dynamics simulation to reveal the biological processes …