Major depressive disorder and type II diabetes mellitus: mechanisms underlying risk for Alzheimer's disease

DS Cha, AF Carvalho, JD Rosenblat… - CNS & Neurological …, 2014 - ingentaconnect.com
Objectives/Introduction: Major Depressive Disorder is associated age-related medical
conditions (eg, diabetes mellitus type II, Alzheimer's disease) that frequently manifest at an …

The complex relationship between depression and dementia

KP Muliyala, M Varghese - Annals of Indian Academy of …, 2010 - journals.lww.com
Dementia and depression are mental health problems that are commonly encountered in
neuropsychiatric practice in the elderly. Approximately, half of the patients with late-onset …

Antidepressant medications in dementia: evidence and potential mechanisms of treatment-resistance

H Costello, JP Roiser, R Howard - Psychological Medicine, 2023 - cambridge.org
Depression in dementia is common, disabling and causes significant distress to patients and
carers. Despite widespread use of antidepressants for depression in dementia, there is no …

Integrated biomarkers for depression in Alzheimer's disease: A critical review

S Wenzler, C Knochel, C Balaban… - Current Alzheimer …, 2017 - ingentaconnect.com
Depression is a common neuropsychiatric manifestation among Alzheimer's disease (AD)
patients. It may compromise everyday activities and lead to a faster cognitive decline as well …

Neuroinflammation: a modifiable pathway linking obesity, alzheimer's disease, and depression

M Ly, ZY Gary, A Mian, A Cramer, S Meysami… - The American Journal of …, 2023 - Elsevier
Obesity, depression and Alzheimer's disease (AD) are three major interrelated modern
health conditions with complex relationships. Early-life depression may serve as a risk factor …

Depression and dementia: cause, consequence or coincidence?

S Bennett, AJ Thomas - Maturitas, 2014 - Elsevier
The relationship between depression and dementia is complex and still not well understood.
A number of different views exist regarding how the two conditions are linked as well as the …

Late-life depression as a risk factor for dementia

I Halperin, AD Korczyn - 2007 - Taylor & Francis
Cognitive dysfunction accompanying depression has been considered to be separate from
dementia and, thus, has been termed pseudodementia, with the presumption that it will …

Depressive symptoms in the elderly—An early symptom of dementia? A systematic review

W Wiels, C Baeken, S Engelborghs - Frontiers in pharmacology, 2020 - frontiersin.org
Background Depression and dementia are common incapacitating diseases in old age. The
exact nature of the relationship between these conditions remains unclear, and multiple …

Shared genetic risk factors for late-life depression and Alzheimer's disease

Q Ye, F Bai, Z Zhang - Journal of Alzheimer's Disease, 2016 - content.iospress.com
Background: Considerable evidence has been reported for the comorbidity between late-life
depression (LLD) and Alzheimer's disease (AD), both of which are very common in the …

Association of amyloid-beta with depression or depressive symptoms in older adults without dementia: a systematic review and meta-analysis

EL Twait, JH Wu, M Kamarioti, M Basten… - Translational …, 2024 - nature.com
Several lines of evidence have indicated that depression might be a prodromal symptom of
Alzheimer's disease (AD). This systematic review and meta-analysis investigated the cross …