Overdose due to opioid abuse is an ever increasing problem, especially in the United
States, with the last few years seeing a dramatic rise in the number of synthetic opioid …

Naloxone is a specific, high affinity opioid antagonist that has been used to treat suspected
or confirmed overdose for more than 40 years. Naloxone use was initially confined to an …

Opioid overdose and mortality have increased at an alarming rate prompting new public
health initiatives to reduce drug poisoning. One initiative is to expand access to the opioid …

Introduction: The initial dose of naloxone administered to patients who present to the
emergency department (ED) with opioid overdose is highly variable. The objective of this …

Acute opioid intoxication and overdose are common causes of presentation to emergency
departments. Although naloxone, a pure opioid antagonist, has been available for many …

Introduction: Opioid overdose fatality has increased threefold since 1999. As a result,
prescription drug overdose surpassed motor vehicle collision as the leading cause of …

Over the past 25 years, naloxone has emerged as a critical lifesaving overdose antidote.
Public health advocates and community activists established early methods for naloxone …

The article discusses the recommendations by the US Food and Drug Administration's (FDA)
Anesthetic and Analgesic Drug Products Advisory Committee on naloxone dose for opioid …

Background The USA has recently entered the third decade of the opioid epidemic. Opioid
overdose deaths reached a new record of over 74,000 in a 12-month period ending April …

With the rise of the opioid epidemic in the United States and increased mortality as a result
of opioid overdoses, there have been many national and statewide initiatives to combat this …