Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones

S Yakar, NP Nunez, P Pennisi, P Brodt, H Sun… - …, 2006 - academic.oup.com
Obesity increases the risk of many cancers in both males and females. This study describes
a link between obesity, obesity-associated metabolic alterations, and the risk of developing …

Obesity accelerates mouse mammary tumor growth in the absence of ovarian hormones

NP Núñez, SN Perkins, NCP Smith, D Berrigan… - Nutrition and …, 2008 - Taylor & Francis
Obesity increases incidence and mortality of breast cancer in postmenopausal women.
Mechanisms underlying this association are poorly understood. Suitable animal models are …

Differential susceptibility to obesity between male, female and ovariectomized female mice

J Hong, RE Stubbins, RR Smith, AE Harvey, NP Núñez - Nutrition journal, 2009 - Springer
Background The prevalence of obesity has increased dramatically. A direct comparison in
the predisposition to obesity between males, premenopausal females, and postmenopausal …

Effects of obesity on hormonally driven cancer in women

KH Moley, GA Colditz - Science translational medicine, 2016 - science.org
Obesity increases the risk of numerous poor health outcomes, including cancer. Obesity is
especially problematic in women because both they and their offspring may be at increased …

Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer

ED Giles, EA Wellberg, DP Astling, SM Anderson… - Cancer research, 2012 - AACR
Obese postmenopausal women have increased risk of breast cancers with poorer clinical
outcomes than their lean counterparts. However, the mechanisms underlying these …

Energy balance modulates colon tumor growth: interactive roles of insulin and estrogen

EA Rondini, AE Harvey, JP Steibel… - Molecular …, 2011 - Wiley Online Library
Obesity increases colorectal cancer (CRC) risk and progression. However, the impact of
obesity on CRC in women is dependent on ovarian hormone status. The purpose of this …

Diet-induced obesity and mammary tumor development in MMTV-neu female mice

MP Cleary, JP Grande, SC Juneja… - Nutrition and cancer, 2004 - Taylor & Francis
Obesity is a risk factor for postmenopausal breast cancer and is associated with shortened
latency and/or increased mammary tumor (MT) incidence in animals. Elevated body weight …

Obesity and cancer

H Ungefroren, F Gieseler, S Fliedner… - … molecular biology and …, 2015 - degruyter.com
The incidence of obesity in the Western world has increased dramatically during the recent
decades. Epidemiological data suggest that obesity is associated with an increased risk of …

The obesity-cancer link: lessons learned from a fatless mouse

SD Hursting, NP Nunez, L Varticovski, C Vinson - Cancer research, 2007 - AACR
Current dogma suggests that the positive correlation between obesity and cancer is driven
by white adipose tissue that accompanies obesity, possibly through excess secretion of …

Obesity increases tumor aggressiveness in a genetically engineered mouse model of serous ovarian cancer

L Makowski, C Zhou, Y Zhong, PF Kuan, C Fan… - Gynecologic …, 2014 - Elsevier
Objectives Obesity is associated with increased risk and worse outcomes for ovarian cancer.
Thus, we examined the effects of obesity on ovarian cancer progression in a genetically …