Flaxseed and its components differentially affect estrogen targets in pre-neoplastic hen ovaries
A Dikshit, C Gao, C Small, K Hales, DB Hales - The Journal of steroid …, 2016 - Elsevier
Flaxseed has been studied for decades for its health benefits that include anti-cancer, cardio-
protective, anti-diabetic, anti-inflammatory properties. The biologically active components …
protective, anti-diabetic, anti-inflammatory properties. The biologically active components …
Whole flaxseed diet alters estrogen metabolism to promote 2-methoxtestradiol-induced apoptosis in hen ovarian cancer
A Dikshit, K Hales, DB Hales - The Journal of nutritional biochemistry, 2017 - Elsevier
The study reported here demonstrates that a flaxseed-supplemented diet causes ovarian
tumors in the laying hen to undergo apoptosis, resulting in a reduction of tumor burden …
tumors in the laying hen to undergo apoptosis, resulting in a reduction of tumor burden …
Flaxseed reduces the pro-carcinogenic micro-environment in the ovaries of normal hens by altering the PG and oestrogen pathways in a dose-dependent manner
A Dikshit, MA Gomes Filho, E Eilati, S McGee… - British Journal of …, 2015 - cambridge.org
The objective of the present study was to find the optimum dose of flaxseed that would
decrease PG and alter oestrogen pathway endpoints implicated in ovarian cancer. In the …
decrease PG and alter oestrogen pathway endpoints implicated in ovarian cancer. In the …
[HTML][HTML] Flaxseed enriched diet-mediated reduction in ovarian cancer severity is correlated to the reduction of prostaglandin E2 in laying hen ovaries
E Eilati, K Hales, Y Zhuge, KA Fricano, R Yu… - … and Essential Fatty …, 2013 - Elsevier
Prevention of ovarian cancer is the best approach for reducing the impact of this deadly
disease. The laying hen is a robust model of spontaneous ovarian cancer that recapitulates …
disease. The laying hen is a robust model of spontaneous ovarian cancer that recapitulates …
Effect of dietary flaxseed on serum levels of estrogens and androgens in postmenopausal women
SR Sturgeon, JL Heersink, SL Volpe… - Nutrition and …, 2008 - Taylor & Francis
Flaxseed is a rich source of dietary lignans. Experimental studies suggest lignans may exert
breast cancer preventive effects through hormonal mechanisms. Our aim was to study the …
breast cancer preventive effects through hormonal mechanisms. Our aim was to study the …
Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in …
Background We have previously shown that a whole flaxseed supplemented diet decreased
the onset and severity of ovarian cancer in the laying hen, the only known animal model of …
the onset and severity of ovarian cancer in the laying hen, the only known animal model of …
Flaxseed oil reduces the growth of human breast tumors (MCF‐7) at high levels of circulating estrogen
JS Truan, JM Chen… - Molecular Nutrition & Food …, 2010 - Wiley Online Library
Flaxseed (FS) has been shown to attenuate mammary tumorigenesis, possibly due to its
high α‐linolenic acid (ALA)‐rich oil (FSO) content. This study determined the effect of FSO …
high α‐linolenic acid (ALA)‐rich oil (FSO) content. This study determined the effect of FSO …
Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen
J Chen, KA Power, J Mann, A Cheng… - Experimental biology …, 2007 - journals.sagepub.com
Flaxseed (FS) is rich in mammalian lignan precursors and α-linolenic acid, which have been
suggested as having anticancer effects. Previous studies have shown that 10% FS inhibits …
suggested as having anticancer effects. Previous studies have shown that 10% FS inhibits …
Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer?
JK Mason, LU Thompson - Applied Physiology, Nutrition, and …, 2014 - cdnsciencepub.com
Flaxseed (FS), rich in the phytoestrogen lignans and α-linolenic acid-rich oil, has been
suggested to have an anticancer effect. Questions remain whether FS and its lignan and oil …
suggested to have an anticancer effect. Questions remain whether FS and its lignan and oil …
[HTML][HTML] Long term consumption of flaxseed enriched diet decreased ovarian cancer incidence and prostaglandin E2 in hens
E Eilati, JM Bahr, DB Hales - Gynecologic oncology, 2013 - Elsevier
Objective Ovarian cancer is the most lethal gynecological malignancy. Prevention may be
the best approach to reduce ovarian cancer. Flaxseed is the richest vegetable source of …
the best approach to reduce ovarian cancer. Flaxseed is the richest vegetable source of …