Contact guidance is a cellular phenomenon observed during wound healing and
developmental patterning, in which adherent cells align in the same direction due to …

A wide variety of cell types exhibit substrate topography-based behavior, also known as
contact guidance. However, the precise cellular mechanisms underlying this process are still …

In vivo, geometric cues from the extracellular matrix (ECM) are critical for the regulation of
cell shape, adhesion, and migration. During contact guidance, the fibrillar architecture of the …

At the edge of a confluent cell layer, cell-free empty space is a cue that can drive directed
collective cellular migration. Similarly, contact guidance is also a robust mechanical cue that …

Topographical patterns are a powerful tool to study directional migration. Grooved
substrates have been extensively used as in vitro models of aligned extracellular matrix …

In the presence of anisotropic biochemical or topographical patterns, cells tend to align in
the direction of these cues—a widely reported phenomenon known as" contact guidance." …

Collective cell migration is fundamental throughout development, during wound healing and
in many diseases. Although much effort has focused on cell–cell junctions, a role for …

Directed migration by contact guidance is a poorly understood yet vital phenomenon,
particularly for carcinoma cell invasion on aligned collagen fibres. We demonstrate that for …

The human corneal basement membrane has a rich felt-like surface topography with feature
dimensions between 20 nm and 200 nm. On the basis of these findings, we designed …

Cell migration is an important biological function that impacts many physiological and
pathological processes. Often migration is directed along aligned fibers of collagen at …